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MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo.
Cavalli G, Hayashi M, Jin Y, Yorgov D, Santorico SA, Holcomb C, Rastrou M, Erlich H, Tengesdal IW, Dagna L, Neff CP, Palmer BE, Spritz RA, Dinarello CA. Cavalli G, et al. Among authors: neff cp. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1363-8. doi: 10.1073/pnas.1523482113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787888 Free PMC article.
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA. Marchetti C, et al. Among authors: neff cp. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29. Proc Natl Acad Sci U S A. 2018. PMID: 29378952 Free PMC article.
Role for nuclear interleukin-37 in the suppression of innate immunity.
Li S, Amo-Aparicio J, Neff CP, Tengesdal IW, Azam T, Palmer BE, López-Vales R, Bufler P, Dinarello CA. Li S, et al. Among authors: neff cp. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4456-4461. doi: 10.1073/pnas.1821111116. Epub 2019 Feb 21. Proc Natl Acad Sci U S A. 2019. PMID: 30792349 Free PMC article.
Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion.
Tengesdal IW, Menon DR, Osborne DG, Neff CP, Powers NE, Gamboni F, Mauro AG, D'Alessandro A, Stefanoni D, Henen MA, Mills TS, De Graaf DM, Azam T, Vogeli B, Palmer BE, Pietras EM, DeGregori J, Tan AC, Joosten LAB, Fujita M, Dinarello CA, Marchetti C. Tengesdal IW, et al. Among authors: neff cp. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2000915118. doi: 10.1073/pnas.2000915118. Proc Natl Acad Sci U S A. 2021. PMID: 33649199 Free PMC article.
Fecal Microbiota Composition Drives Immune Activation in HIV-infected Individuals.
Neff CP, Krueger O, Xiong K, Arif S, Nusbacher N, Schneider JM, Cunningham AW, Armstrong A, Li S, McCarter MD, Campbell TB, Lozupone CA, Palmer BE. Neff CP, et al. EBioMedicine. 2018 Apr;30:192-202. doi: 10.1016/j.ebiom.2018.03.024. Epub 2018 Mar 26. EBioMedicine. 2018. PMID: 29650491 Free PMC article.
45 results