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A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Böhnke N, Berger M, Griebenow N, Rottmann A, Erkelenz M, Hammer S, Berndt S, Günther J, Wengner AM, Stelte-Ludwig B, Mahlert C, Greven S, Dietz L, Jörißen H, Barak N, Bömer U, Hillig RC, Eberspaecher U, Weiske J, Giese A, Mumberg D, Nising CF, Weinmann H, Sommer A. Böhnke N, et al. Among authors: giese a. Bioconjug Chem. 2022 Jun 15;33(6):1210-1221. doi: 10.1021/acs.bioconjchem.2c00178. Epub 2022 Jun 3. Bioconjug Chem. 2022. PMID: 35658441 Free PMC article.
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
Ellermann M, Eheim A, Rahm F, Viklund J, Guenther J, Andersson M, Ericsson U, Forsblom R, Ginman T, Lindström J, Silvander C, Trésaugues L, Giese A, Bunse S, Neuhaus R, Weiske J, Quanz M, Glasauer A, Nowak-Reppel K, Bader B, Irlbacher H, Meyer H, Queisser N, Bauser M, Haegebarth A, Gorjánácz M. Ellermann M, et al. Among authors: giese a. ACS Chem Biol. 2017 Aug 18;12(8):1986-1992. doi: 10.1021/acschembio.7b00370. Epub 2017 Jul 12. ACS Chem Biol. 2017. PMID: 28679043 Free article.
Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.
Rahm F, Viklund J, Trésaugues L, Ellermann M, Giese A, Ericsson U, Forsblom R, Ginman T, Günther J, Hallberg K, Lindström J, Persson LB, Silvander C, Talagas A, Díaz-Sáez L, Fedorov O, Huber KVM, Panagakou I, Siejka P, Gorjánácz M, Bauser M, Andersson M. Rahm F, et al. Among authors: giese a. J Med Chem. 2018 Mar 22;61(6):2533-2551. doi: 10.1021/acs.jmedchem.7b01884. Epub 2018 Mar 7. J Med Chem. 2018. PMID: 29485874
Linker-Dependent Folding Rationalizes PROTAC Cell Permeability.
Poongavanam V, Atilaw Y, Siegel S, Giese A, Lehmann L, Meibom D, Erdelyi M, Kihlberg J. Poongavanam V, et al. Among authors: giese a. J Med Chem. 2022 Oct 13;65(19):13029-13040. doi: 10.1021/acs.jmedchem.2c00877. Epub 2022 Sep 28. J Med Chem. 2022. PMID: 36170570 Free PMC article.
Solution Conformations Shed Light on PROTAC Cell Permeability.
Atilaw Y, Poongavanam V, Svensson Nilsson C, Nguyen D, Giese A, Meibom D, Erdelyi M, Kihlberg J. Atilaw Y, et al. Among authors: giese a. ACS Med Chem Lett. 2020 Dec 25;12(1):107-114. doi: 10.1021/acsmedchemlett.0c00556. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488971 Free PMC article.
Predictive Modeling of PROTAC Cell Permeability with Machine Learning.
Poongavanam V, Kölling F, Giese A, Göller AH, Lehmann L, Meibom D, Kihlberg J. Poongavanam V, et al. Among authors: giese a. ACS Omega. 2023 Feb 1;8(6):5901-5916. doi: 10.1021/acsomega.2c07717. eCollection 2023 Feb 14. ACS Omega. 2023. PMID: 36816707 Free PMC article.
Inflammatory biomarker analysis confirms reduced disease severity in heterozygous patients with familial Mediterranean fever.
Elhani I, Backes S, Kallinich T, Amaryan G, Belot A, Berendes R, Berger T, Dressler F, Foell D, Fühner S, Giese A, Hinze C, Hitzegrad AL, Horneff G, Jansson A, Klotsche J, Lainka E, Niehues T, Oommen P, Haas JP, Rietschel C, Theodoropoulo K, Vinit C, Weissbarth-Riedel E, Hentgen V, Wittkowski H. Elhani I, et al. Among authors: giese a. RMD Open. 2024 Nov 24;10(4):e004677. doi: 10.1136/rmdopen-2024-004677. RMD Open. 2024. PMID: 39581688 Free PMC article.
The association of SUR1 polymorphisms with acute infarct size: The MRI-GENIE study.
Deng A, Xu H, Gaynor BJ, Cole JW, Giese AK, Schirmer MD, McArdle PF, Mitchell BD, Wu O, Rost NS, Kittner SJ; MRI-GENIE Investigators. Deng A, et al. Among authors: giese ak. J Stroke Cerebrovasc Dis. 2025 Jan;34(1):108109. doi: 10.1016/j.jstrokecerebrovasdis.2024.108109. Epub 2024 Nov 1. J Stroke Cerebrovasc Dis. 2025. PMID: 39489406 Free article.
678 results