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Diastereoselectivity is in the Details: Minor Changes Yield Major Improvements to the Synthesis of Bedaquiline.
Chemistry. 2022 Aug 22;28(47):e202201311. doi: 10.1002/chem.202201311. Epub 2022 Jul 7.
Chemistry. 2022.
PMID: 35675114
Free PMC article.
Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline.
Robey JMS, Maity S, Aleshire SL, Ghosh A, Yadaw AK, Roy S, Mear SJ, Jamison TF, Sirasani G, Senanayake CH, Stringham RW, Gupton BF, Donsbach KO, Nelson RC, Shanahan CS.
Robey JMS, et al.
Org Process Res Dev. 2023 Oct 13;27(11):2146-2159. doi: 10.1021/acs.oprd.3c00287. eCollection 2023 Nov 17.
Org Process Res Dev. 2023.
PMID: 38025988
Free PMC article.
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