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A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation.
Hansen JN, Kaiser F, Leyendecker P, Stüven B, Krause JH, Derakhshandeh F, Irfan J, Sroka TJ, Preval KM, Desai PB, Kraut M, Theis H, Drews AD, De-Domenico E, Händler K, Pazour GJ, Henderson DJP, Mick DU, Wachten D. Hansen JN, et al. Among authors: pazour gj. EMBO Rep. 2022 Aug 3;23(8):e54315. doi: 10.15252/embr.202154315. Epub 2022 Jun 13. EMBO Rep. 2022. PMID: 35695071 Free PMC article.
Autonomous and non-cell autonomous etiology of ciliopathy associated structural birth defects.
Francis R, San Agustin JT, Szabo Rogers HL, Cui C, Jonassen JA, Eguether T, Follit JA, Lo CW, Pazour GJ. Francis R, et al. Among authors: pazour gj. bioRxiv [Preprint]. 2023 Jun 7:2023.06.07.544132. doi: 10.1101/2023.06.07.544132. bioRxiv. 2023. Update in: PLoS Biol. 2023 Dec 11;21(12):e3002425. doi: 10.1371/journal.pbio.3002425 PMID: 37333142 Free PMC article. Updated. Preprint.
Cilia in cystic kidney and other diseases.
Pazour GJ, Quarmby L, Smith AO, Desai PB, Schmidts M. Pazour GJ, et al. Cell Signal. 2020 May;69:109519. doi: 10.1016/j.cellsig.2019.109519. Epub 2019 Dec 24. Cell Signal. 2020. PMID: 31881326 Free PMC article. Review.
The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) oncogene is upregulated in pre-cystic epithelial cells revealing a new target for polycystic kidney disease.
Smith AO, Frantz WT, Preval KM, Edwards YJK, Ceol CJ, Jonassen JA, Pazour GJ. Smith AO, et al. Among authors: pazour gj. medRxiv [Preprint]. 2023 Dec 4:2023.12.04.23299387. doi: 10.1101/2023.12.04.23299387. medRxiv. 2023. Update in: PLoS Genet. 2024 Dec 12;20(12):e1011510. doi: 10.1371/journal.pgen.1011510 PMID: 38106222 Free PMC article. Updated. Preprint.
140 results