Makino C - Search Results

1

Species differences between rats and primates (humans and monkeys) in complex cleavage pathways of DS-8500a characterized by ¹⁴C-ADME studies in humans and monkeys after administration of two radiolabeled compounds and in vitro studies.

Makino C, Watanabe A, Kato M, Shiozawa H, Takakusa H, Nakai D, Honda T, Watanabe N. Makino C, et al. Drug Metab Pharmacokinet. 2022 Aug;45:100459. doi: 10.1016/j.dmpk.2022.100459. Epub 2022 Mar 19. Drug Metab Pharmacokinet. 2022. PMID: 35716472

2

Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity.

Takakusa H, Masumoto H, Yukinaga H, Makino C, Nakayama S, Okazaki O, Sudo K. Takakusa H, et al. Among authors: makino c. Drug Metab Dispos. 2008 Sep;36(9):1770-9. doi: 10.1124/dmd.108.021725. Epub 2008 May 28. Drug Metab Dispos. 2008. PMID: 18508880

3

Quantitative assessment of reactive metabolite formation using 35S-labeled glutathione.

Takakusa H, Masumoto H, Makino C, Okazaki O, Sudo K. Takakusa H, et al. Among authors: makino c. Drug Metab Pharmacokinet. 2009;24(1):100-7. doi: 10.2133/dmpk.24.100. Drug Metab Pharmacokinet. 2009. PMID: 19252339 Free article.

4

In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions.

Makino C, Watanabe A, Deguchi T, Shiozawa H, Schreck I, Rozehnal V, Ishizuka T, Watanabe N, Ando O, Murayama N, Yamazaki H. Makino C, et al. Xenobiotica. 2019 Aug;49(8):961-969. doi: 10.1080/00498254.2018.1514545. Epub 2018 Sep 28. Xenobiotica. 2019. PMID: 30124356

5

Pharmacokinetics of the Multi-kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality.

Zahir H, Greenberg J, Hsu C, Watanabe K, Makino C, He L, LaCreta F. Zahir H, et al. Among authors: makino c. Clin Pharmacol Drug Dev. 2023 Feb;12(2):159-167. doi: 10.1002/cpdd.1186. Epub 2022 Nov 11. Clin Pharmacol Drug Dev. 2023. PMID: 36369799 Free PMC article.

6

Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.

Masubuchi N, Makino C, Murayama N. Masubuchi N, et al. Among authors: makino c. Chem Res Toxicol. 2007 Mar;20(3):455-64. doi: 10.1021/tx060234h. Epub 2007 Feb 20. Chem Res Toxicol. 2007. PMID: 17309281

7

In vitro evaluation of the potential for drug-induced toxicity based on (35)S-labeled glutathione adduct formation and daily dose.

Miyaji Y, Makino C, Kurihara A, Suzuki W, Okazaki O. Miyaji Y, et al. Among authors: makino c. Bioanalysis. 2012 Feb;4(3):263-9. doi: 10.4155/bio.11.316. Bioanalysis. 2012. PMID: 22303830

8

Bicarbonate boosts flash response amplitude to augment absolute sensitivity and extend dynamic range in murine retinal rods.

Adhikari RD, Kossoff AM, Cornwall MC, Makino CL. Adhikari RD, et al. Among authors: makino cl. Front Mol Neurosci. 2023 Apr 14;16:1125006. doi: 10.3389/fnmol.2023.1125006. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37122625 Free PMC article.

9

Editorial: Multi-limbed membrane guanylate cyclase cellular signaling pathways.

Sharma RK, Pandey KN, Duda T, Makino CL. Sharma RK, et al. Among authors: makino cl. Front Mol Neurosci. 2023 Apr 12;16:1185637. doi: 10.3389/fnmol.2023.1185637. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37122624 Free PMC article. No abstract available.

10

Pepperberg plot: Modeling flash response saturation in retinal rods of mouse.

Caruso G, Klaus C, Hamm HE, Gurevich VV, Bisegna P, Andreucci D, DiBenedetto E, Makino CL. Caruso G, et al. Among authors: makino cl. Front Mol Neurosci. 2023 Jan 13;15:1054449. doi: 10.3389/fnmol.2022.1054449. eCollection 2022. Front Mol Neurosci. 2023. PMID: 36710929 Free PMC article.

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