Johnson TR - Search Results

1

Analysis of lorlatinib analogs reveals a roadmap for targeting diverse compound resistance mutations in ALK-positive lung cancer.

Shiba-Ishii A, Johnson TW, Dagogo-Jack I, Mino-Kenudson M, Johnson TR, Wei P, Weinrich SL, McTigue MA, Walcott MA, Nguyen-Phuong L, Dionne K, Acker A, Kiedrowski LA, Do A, Peterson JL, Barth JL, Yeap BY, Gainor JF, Lin JJ, Yoda S, Hata AN. Shiba-Ishii A, et al. Among authors: johnson tw, johnson tr. Nat Cancer. 2022 Jun;3(6):710-722. doi: 10.1038/s43018-022-00399-6. Epub 2022 Jun 20. Nat Cancer. 2022. PMID: 35726063 Free PMC article.

2

Effects of Renal Function on Crizotinib Pharmacokinetics: Dose Recommendations for Patients with ALK-Positive Non-Small Cell Lung Cancer.

Tan W, Yamazaki S, Johnson TR, Wang R, O'Gorman MT, Kirkovsky L, Boutros T, Brega NM, Bello A. Tan W, et al. Among authors: johnson tr. Clin Drug Investig. 2017 Apr;37(4):363-373. doi: 10.1007/s40261-016-0490-z. Clin Drug Investig. 2017. PMID: 28035616

3

Liver Toxicity Observed With Lorlatinib When Combined With Strong CYP3A Inducers: Evaluation of Cynomolgus Monkey as a Nonclinical Model for Assessing the Mechanism of Combinational Toxicity.

Hu W, Lettiere D, Tse S, Johnson TR, Biddle KE, Thibault S, Palazzi X, Chen J, Pithavala YK, Finkelstein M. Hu W, et al. Among authors: johnson tr. Toxicol Sci. 2021 Aug 3;182(2):183-194. doi: 10.1093/toxsci/kfab056. Toxicol Sci. 2021. PMID: 34021354

4

Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer.

Lee C, Jiang ZK, Planken S, Manzuk LK, Ortiz R, Hall M, Noorbehesht K, Ram S, Affolter T, Troche GE, Ihle NT, Johnson T, Ahn Y, Kraus M, Giddabasappa A. Lee C, et al. Mol Cancer Ther. 2023 Jul 5;22(7):891-900. doi: 10.1158/1535-7163.MCT-22-0810. Mol Cancer Ther. 2023. PMID: 37186518 Free PMC article.

5

Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects.

Johnson TR, Tan W, Goulet L, Smith EB, Yamazaki S, Walker GS, O'Gorman MT, Bedarida G, Zou HY, Christensen JG, Nguyen LN, Shen Z, Dalvie D, Bello A, Smith BJ. Johnson TR, et al. Xenobiotica. 2015 Jan;45(1):45-59. doi: 10.3109/00498254.2014.941964. Epub 2014 Jul 18. Xenobiotica. 2015. PMID: 25034009

6

Crizotinib reduces the rate of dark adaptation in the rat retina independent of ALK inhibition.

Liu CN, Mathialagan N, Lappin P, Fortner J, Somps C, Seitis G, Johnson TR, Hu W, Matsumoto D. Liu CN, et al. Among authors: johnson tr. Toxicol Sci. 2015 Jan;143(1):116-25. doi: 10.1093/toxsci/kfu213. Epub 2014 Oct 16. Toxicol Sci. 2015. PMID: 25326243

7

Prediction of crizotinib-midazolam interaction using the Simcyp population-based simulator: comparison of CYP3A time-dependent inhibition between human liver microsomes versus hepatocytes.

Mao J, Johnson TR, Shen Z, Yamazaki S. Mao J, et al. Among authors: johnson tr. Drug Metab Dispos. 2013 Feb;41(2):343-52. doi: 10.1124/dmd.112.049114. Epub 2012 Nov 5. Drug Metab Dispos. 2013. PMID: 23129213

8

Prediction of Drug-Drug Interactions with Crizotinib as the CYP3A Substrate Using a Physiologically Based Pharmacokinetic Model.

Yamazaki S, Johnson TR, Smith BJ. Yamazaki S, et al. Among authors: johnson tr. Drug Metab Dispos. 2015 Oct;43(10):1417-29. doi: 10.1124/dmd.115.064618. Epub 2015 Jul 15. Drug Metab Dispos. 2015. PMID: 26180127 Clinical Trial.

9

Metabolism, Excretion, and Pharmacokinetics of Lorlatinib (PF-06463922) and Evaluation of the Impact of Radiolabel Position and Other Factors on Comparability of Data Across 2 ADME Studies.

Stypinski D, Fostvedt L, Lam JL, Vaz A, Johnson TR, Boerma JS, Pithavala YK. Stypinski D, et al. Among authors: johnson tr. J Clin Pharmacol. 2020 Sep;60(9):1254-1267. doi: 10.1002/jcph.1621. Epub 2020 May 22. J Clin Pharmacol. 2020. PMID: 32441835

10

Epidemiology of Patient Record Duplication.

Sahin O, Zhao A, Applegate RJ, Johnson TR, Bernstam EV. Sahin O, et al. Among authors: johnson tr. Appl Clin Inform. 2025 Jan;16(1):24-30. doi: 10.1055/a-2423-8499. Epub 2024 Sep 27. Appl Clin Inform. 2025. PMID: 39333060

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