Zhang S - Search Results

1

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases.

Blevins HM, Xu Y, Biby S, Zhang S. Blevins HM, et al. Among authors: zhang s. Front Aging Neurosci. 2022 Jun 10;14:879021. doi: 10.3389/fnagi.2022.879021. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35754962 Free PMC article. Review.

2

Development of bivalent compounds as potential neuroprotectants for Alzheimer's disease.

He L, Jiang Y, Green J, Blevins H, Zhang S. He L, et al. Among authors: zhang s. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1957-1961. doi: 10.1016/j.bmcl.2019.05.035. Epub 2019 May 18. Bioorg Med Chem Lett. 2019. PMID: 31153803 Free PMC article.

3

Discovery of Second-Generation NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization.

Jiang Y, He L, Green J, Blevins H, Guo C, Patel SH, Halquist MS, McRae M, Venitz J, Wang XY, Zhang S. Jiang Y, et al. Among authors: zhang s. J Med Chem. 2019 Nov 14;62(21):9718-9731. doi: 10.1021/acs.jmedchem.9b01155. Epub 2019 Oct 31. J Med Chem. 2019. PMID: 31626545 Free PMC article.

4

Characterization and Discovery of a Selective Small-Molecule Modulator of Mitochondrial Complex I Targeting a Unique Binding Site.

Green JC, Jiang Y, He L, Xu Y, Sun D, Keoprasert T, Nelson C, Oh U, Lesnefsky EJ, Kellogg GE, Chen Q, Zhang S. Green JC, et al. Among authors: zhang s. J Med Chem. 2020 Oct 22;63(20):11819-11830. doi: 10.1021/acs.jmedchem.0c01021. Epub 2020 Oct 2. J Med Chem. 2020. PMID: 32945676 Free PMC article.

5

Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome.

Xu Y, Xu Y, Blevins H, Lan Y, Liu Y, Yuan G, Striar R, Zagaroli JS, Tocci DR, Langan AG, Zhang C, Zhang S, Wang C. Xu Y, et al. Among authors: zhang c, zhang s. Bioorg Med Chem Lett. 2021 Feb 15;34:127777. doi: 10.1016/j.bmcl.2021.127777. Epub 2021 Jan 6. Bioorg Med Chem Lett. 2021. PMID: 33418063 Free PMC article.

6

Structural understanding of 5-(4-hydroxy-phenyl)-N-(2-(5-methoxy-1H-indol-3-yl)-ethyl)-3-oxopentanamide as a neuroprotectant for Alzheimer's disease.

Saathoff J, Green J, Jiang Y, Xu Y, Kellogg GE, Zhang S. Saathoff J, et al. Among authors: zhang s. Bioorg Med Chem Lett. 2021 Jul 1;43:128081. doi: 10.1016/j.bmcl.2021.128081. Epub 2021 May 5. Bioorg Med Chem Lett. 2021. PMID: 33964442 Free PMC article.

7

A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer's Disease Transgenic Mice.

Kuwar R, Rolfe A, Di L, Blevins H, Xu Y, Sun X, Bloom GS, Zhang S, Sun D. Kuwar R, et al. Among authors: zhang s. J Alzheimers Dis. 2021;82(4):1769-1783. doi: 10.3233/JAD-210400. J Alzheimers Dis. 2021. PMID: 34219728 Free PMC article.

8

Novel Positron Emission Tomography Radiotracers for Imaging Mitochondrial Complex I.

Xu Y, Xu Y, Biby S, Bai P, Liu Y, Zhang C, Wang C, Zhang S. Xu Y, et al. Among authors: zhang c, zhang s. ACS Chem Neurosci. 2021 Dec 15;12(24):4491-4499. doi: 10.1021/acschemneuro.1c00297. Epub 2021 Nov 23. ACS Chem Neurosci. 2021. PMID: 34812607 Free PMC article.

9

Development of sulfonamide-based NLRP3 inhibitors: Further modifications and optimization through structure-activity relationship studies.

Xu Y, Xu Y, Blevins H, Guo C, Biby S, Wang XY, Wang C, Zhang S. Xu Y, et al. Among authors: zhang s. Eur J Med Chem. 2022 Aug 5;238:114468. doi: 10.1016/j.ejmech.2022.114468. Epub 2022 May 21. Eur J Med Chem. 2022. PMID: 35635948 Free PMC article.

10

A patent review of NLRP3 inhibitors to treat autoimmune diseases.

Xu Y, Biby S, Kaur B, Zhang S. Xu Y, et al. Among authors: zhang s. Expert Opin Ther Pat. 2023 Jan-Jun;33(6):455-470. doi: 10.1080/13543776.2023.2239502. Epub 2023 Jul 26. Expert Opin Ther Pat. 2023. PMID: 37470439 Free PMC article. Review.

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