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High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells.
Chen JS, Chow RD, Song E, Mao T, Israelow B, Kamath K, Bozekowski J, Haynes WA, Filler RB, Menasche BL, Wei J, Alfajaro MM, Song W, Peng L, Carter L, Weinstein JS, Gowthaman U, Chen S, Craft J, Shon JC, Iwasaki A, Wilen CB, Eisenbarth SC. Chen JS, et al. Among authors: chen s. Sci Immunol. 2022 Feb 4;7(68):eabl5652. doi: 10.1126/sciimmunol.abl5652. Epub 2022 Feb 4. Sci Immunol. 2022. PMID: 34914544 Free PMC article.
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617.
Peng L, Hu Y, Mankowski MC, Ren P, Chen RE, Wei J, Zhao M, Li T, Tripler T, Ye L, Chow RD, Fang Z, Wu C, Dong MB, Cook M, Wang G, Clark P, Nelson B, Klein D, Sutton R, Diamond MS, Wilen CB, Xiong Y, Chen S. Peng L, et al. Among authors: chen re, chen s. bioRxiv [Preprint]. 2021 Dec 24:2021.12.21.473733. doi: 10.1101/2021.12.21.473733. bioRxiv. 2021. Update in: Nat Commun. 2022 Mar 28;13(1):1638. doi: 10.1038/s41467-022-29288-3 PMID: 34981065 Free PMC article. Updated. Preprint.
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2.
Fang Z, Peng L, Filler R, Suzuki K, McNamara A, Lin Q, Renauer PA, Yang L, Menasche B, Sanchez A, Ren P, Xiong Q, Strine M, Clark P, Lin C, Ko AI, Grubaugh ND, Wilen CB, Chen S. Fang Z, et al. Among authors: chen s. bioRxiv [Preprint]. 2022 Feb 28:2022.02.14.480449. doi: 10.1101/2022.02.14.480449. bioRxiv. 2022. Update in: Nat Commun. 2022 Jun 6;13(1):3250. doi: 10.1038/s41467-022-30878-4 PMID: 35194606 Free PMC article. Updated. Preprint.
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy.
Ye L, Park JJ, Peng L, Yang Q, Chow RD, Dong MB, Lam SZ, Guo J, Tang E, Zhang Y, Wang G, Dai X, Du Y, Kim HR, Cao H, Errami Y, Clark P, Bersenev A, Montgomery RR, Chen S. Ye L, et al. Among authors: chen s. Cell Metab. 2022 Apr 5;34(4):595-614.e14. doi: 10.1016/j.cmet.2022.02.009. Epub 2022 Mar 10. Cell Metab. 2022. PMID: 35276062 Free PMC article.
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617.
Peng L, Hu Y, Mankowski MC, Ren P, Chen RE, Wei J, Zhao M, Li T, Tripler T, Ye L, Chow RD, Fang Z, Wu C, Dong MB, Cook M, Wang G, Clark P, Nelson B, Klein D, Sutton R, Diamond MS, Wilen CB, Xiong Y, Chen S. Peng L, et al. Among authors: chen re, chen s. Nat Commun. 2022 Mar 28;13(1):1638. doi: 10.1038/s41467-022-29288-3. Nat Commun. 2022. PMID: 35347138 Free PMC article.
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2.
Fang Z, Peng L, Filler R, Suzuki K, McNamara A, Lin Q, Renauer PA, Yang L, Menasche B, Sanchez A, Ren P, Xiong Q, Strine M, Clark P, Lin C, Ko AI, Grubaugh ND, Wilen CB, Chen S. Fang Z, et al. Among authors: chen s. Nat Commun. 2022 Jun 6;13(1):3250. doi: 10.1038/s41467-022-30878-4. Nat Commun. 2022. PMID: 35668119 Free PMC article.
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