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Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Ocaña A, Tersey SA, Mirmira RG. Levasseur EM, et al. Among authors: orr ks. Sci Signal. 2019 Dec 3;12(610):eaax0715. doi: 10.1126/scisignal.aax0715. Sci Signal. 2019. PMID: 31796630 Free PMC article.
Oligomeric collagen as an encapsulation material for islet/β-cell replacement: effect of islet source, dose, implant site, and administration format.
Stephens CH, Morrison RA, McLaughlin M, Orr K, Tersey SA, Scott-Moncrieff JC, Mirmira RG, Considine RV, Voytik-Harbin S. Stephens CH, et al. Am J Physiol Endocrinol Metab. 2020 Aug 1;319(2):E388-E400. doi: 10.1152/ajpendo.00066.2020. Epub 2020 Jun 16. Am J Physiol Endocrinol Metab. 2020. PMID: 32543944 Free PMC article.
Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice.
Syed F, Ballew O, Lee CC, Rana J, Krishnan P, Castela A, Weaver SA, Chalasani NS, Thomaidou SF, Demine S, Chang G, Coomans de Brachène A, Alvelos MI, Marselli L, Orr K, Felton JL, Liu J, Marchetti P, Zaldumbide A, Scheuner D, Eizirik DL, Evans-Molina C. Syed F, et al. bioRxiv [Preprint]. 2024 May 9:2024.03.20.585925. doi: 10.1101/2024.03.20.585925. bioRxiv. 2024. PMID: 38766166 Free PMC article. Preprint.
Mechanisms of spinophilin-dependent pancreas dysregulation in obesity.
Stickel KC, Shah NR, Claeboe ET, Orr KS, Mosley AL, Doud EH, Belecky-Adams TL, Baucum AJ. Stickel KC, et al. Among authors: orr ks. Am J Physiol Endocrinol Metab. 2024 Aug 1;327(2):E155-E171. doi: 10.1152/ajpendo.00099.2023. Epub 2024 Apr 17. Am J Physiol Endocrinol Metab. 2024. PMID: 38630048 Free PMC article.
19 results