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C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.
Amici DR, Ansel DJ, Metz KA, Smith RS, Phoumyvong CM, Gayatri S, Chamera T, Edwards SL, O'Hara BP, Srivastava S, Brockway S, Takagishi SR, Cho BK, Goo YA, Kelleher NL, Ben-Sahra I, Foltz DR, Li J, Mendillo ML. Amici DR, et al. Proc Natl Acad Sci U S A. 2022 Jul 5;119(27):e2111262119. doi: 10.1073/pnas.2111262119. Epub 2022 Jul 1. Proc Natl Acad Sci U S A. 2022. PMID: 35776542 Free PMC article.
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.
Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G. Soflaee MH, et al. Nat Commun. 2022 May 16;13(1):2698. doi: 10.1038/s41467-022-30362-z. Nat Commun. 2022. PMID: 35577785 Free PMC article.
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia.
Jin Q, Gutierrez Diaz B, Pieters T, Zhou Y, Narang S, Fijalkwoski I, Borin C, Van Laere J, Payton M, Cho BK, Han C, Sun L, Serafin V, Yacu G, Von Loocke W, Basso G, Veltri G, Dreveny I, Ben-Sahra I, Goo YA, Safgren SL, Tsai YC, Bornhauser B, Suraneni PK, Gaspar-Maia A, Kandela I, Van Vlierberghe P, Crispino JD, Tsirigos A, Ntziachristos P. Jin Q, et al. Sci Adv. 2022 Dec 9;8(49):eabq8437. doi: 10.1126/sciadv.abq8437. Epub 2022 Dec 9. Sci Adv. 2022. PMID: 36490346 Free PMC article.
Dual Covalent Inhibition of PKM and IMPDH Targets Metabolism in Cutaneous Metastatic Melanoma.
Zerhouni M, Martin AR, Furstoss N, Gutierrez VS, Jaune E, Tekaya N, Beranger GE, Abbe P, Regazzetti C, Amdouni H, Driowya M, Dubreuil P, Luciano F, Jacquel A, Tulic MK, Cluzeau T, O'Hara BP, Ben-Sahra I, Passeron T, Benhida R, Robert G, Auberger P, Rocchi S. Zerhouni M, et al. Cancer Res. 2021 Jul 15;81(14):3806-3821. doi: 10.1158/0008-5472.CAN-20-2114. Epub 2021 Jun 7. Cancer Res. 2021. PMID: 34099492
mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function.
Sato T, Chang HC, Bayeva M, Shapiro JS, Ramos-Alonso L, Kouzu H, Jiang X, Liu T, Yar S, Sawicki KT, Chen C, Martínez-Pastor MT, Stumpo DJ, Schumacker PT, Blackshear PJ, Ben-Sahra I, Puig S, Ardehali H. Sato T, et al. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6291-E6300. doi: 10.1073/pnas.1804701115. Epub 2018 Jun 18. Proc Natl Acad Sci U S A. 2018. PMID: 29915044 Free PMC article.
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