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TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias.
Vandewiele F, Pironet A, Jacobs G, Kecskés M, Wegener J, Kerselaers S, Hendrikx L, Verelst J, Philippaert K, Oosterlinck W, Segal A, Van Den Broeck E, Pinto S, Priori SG, Lehnart SE, Nilius B, Voets T, Vennekens R. Vandewiele F, et al. Among authors: segal a. Eur Heart J. 2022 Oct 21;43(40):4195-4207. doi: 10.1093/eurheartj/ehac354. Eur Heart J. 2022. PMID: 35822895
Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity.
Philippaert K, Pironet A, Mesuere M, Sones W, Vermeiren L, Kerselaers S, Pinto S, Segal A, Antoine N, Gysemans C, Laureys J, Lemaire K, Gilon P, Cuypers E, Tytgat J, Mathieu C, Schuit F, Rorsman P, Talavera K, Voets T, Vennekens R. Philippaert K, et al. Among authors: segal a. Nat Commun. 2017 Mar 31;8:14733. doi: 10.1038/ncomms14733. Nat Commun. 2017. PMID: 28361903 Free PMC article.
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice.
Colsoul B, Schraenen A, Lemaire K, Quintens R, Van Lommel L, Segal A, Owsianik G, Talavera K, Voets T, Margolskee RF, Kokrashvili Z, Gilon P, Nilius B, Schuit FC, Vennekens R. Colsoul B, et al. Among authors: segal a. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5208-13. doi: 10.1073/pnas.0913107107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194741 Free PMC article.
A TRP channel trio mediates acute noxious heat sensing.
Vandewauw I, De Clercq K, Mulier M, Held K, Pinto S, Van Ranst N, Segal A, Voet T, Vennekens R, Zimmermann K, Vriens J, Voets T. Vandewauw I, et al. Among authors: segal a. Nature. 2018 Mar 29;555(7698):662-666. doi: 10.1038/nature26137. Epub 2018 Mar 14. Nature. 2018. PMID: 29539642
1,149 results