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Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists.
Connors J, Taramangalam B, Cusimano G, Bell MR, Matt SM, Runner K, Gaskill PJ, DeFilippis V, Nikolich-Žugich J, Kutzler MA, Haddad EK. Connors J, et al. Among authors: defilippis v. Geroscience. 2022 Oct;44(5):2555-2572. doi: 10.1007/s11357-022-00612-5. Epub 2022 Jul 18. Geroscience. 2022. PMID: 35849213 Free PMC article.
Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus.
Uhrlaub JL, Pulko V, DeFilippis VR, Broeckel R, Streblow DN, Coleman GD, Park BS, Lindo JF, Vickers I, Anzinger JJ, Nikolich-Žugich J. Uhrlaub JL, et al. Among authors: defilippis vr. PLoS Pathog. 2016 Oct 13;12(10):e1005891. doi: 10.1371/journal.ppat.1005891. eCollection 2016 Oct. PLoS Pathog. 2016. PMID: 27736984 Free PMC article.
65 results