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Page 1
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity.
Darwish S, Ghazy E, Heimburg T, Herp D, Zeyen P, Salem-Altintas R, Ridinger J, Robaa D, Schmidtkunz K, Erdmann F, Schmidt M, Romier C, Jung M, Oehme I, Sippl W. Darwish S, et al. Among authors: zeyen p. Int J Mol Sci. 2022 Jul 7;23(14):7535. doi: 10.3390/ijms23147535. Int J Mol Sci. 2022. PMID: 35886887 Free PMC article.
Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity.
Heimburg T, Kolbinger FR, Zeyen P, Ghazy E, Herp D, Schmidtkunz K, Melesina J, Shaik TB, Erdmann F, Schmidt M, Romier C, Robaa D, Witt O, Oehme I, Jung M, Sippl W. Heimburg T, et al. Among authors: zeyen p. J Med Chem. 2017 Dec 28;60(24):10188-10204. doi: 10.1021/acs.jmedchem.7b01447. Epub 2017 Dec 15. J Med Chem. 2017. PMID: 29190092
Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.
Ghazy E, Heimburg T, Lancelot J, Zeyen P, Schmidtkunz K, Truhn A, Darwish S, Simoben CV, Shaik TB, Erdmann F, Schmidt M, Robaa D, Romier C, Jung M, Pierce R, Sippl W. Ghazy E, et al. Among authors: zeyen p. Eur J Med Chem. 2021 Dec 5;225:113745. doi: 10.1016/j.ejmech.2021.113745. Epub 2021 Aug 8. Eur J Med Chem. 2021. PMID: 34392190
Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity.
Ibrahim HS, Abdelsalam M, Zeyn Y, Zessin M, Mustafa AM, Fischer MA, Zeyen P, Sun P, Bülbül EF, Vecchio A, Erdmann F, Schmidt M, Robaa D, Barinka C, Romier C, Schutkowski M, Krämer OH, Sippl W. Ibrahim HS, et al. Among authors: zeyen p. Int J Mol Sci. 2021 Dec 29;23(1):369. doi: 10.3390/ijms23010369. Int J Mol Sci. 2021. PMID: 35008795 Free PMC article.
The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs.
Vaca HR, Celentano AM, Toscanini MA, Heimburg T, Ghazy E, Zeyen P, Hauser AT, Oliveira G, Elissondo MC, Jung M, Sippl W, Camicia F, Rosenzvit MC. Vaca HR, et al. Among authors: zeyen p. PLoS Negl Trop Dis. 2021 Mar 3;15(3):e0009226. doi: 10.1371/journal.pntd.0009226. eCollection 2021 Mar. PLoS Negl Trop Dis. 2021. PMID: 33657105 Free PMC article.
Psychological outcomes of dementia risk estimation in MCI patients: Results from the PreDADQoL project.
Rostamzadeh A, Kalthegener F, Schwegler C, Romotzky V, Gil-Navarro S, Rosende-Roca M, Ortega G, Canabate P, Moreno M, Maier F, Zeyen P, Schild AK, Meiberth D, Sannemann L, Bohr L, Schmitz-Luhn B, Boada M, Woopen C, Jessen F. Rostamzadeh A, et al. Among authors: zeyen p. Alzheimers Dement. 2024 Nov;20(11):7635-7656. doi: 10.1002/alz.14226. Epub 2024 Oct 1. Alzheimers Dement. 2024. PMID: 39351885 Free PMC article.
22 results