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Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.
Storer RI, Pike A, Swain NA, Alexandrou AJ, Bechle BM, Blakemore DC, Brown AD, Castle NA, Corbett MS, Flanagan NJ, Fengas D, Johnson MS, Jones LH, Marron BE, Payne CE, Printzenhoff D, Rawson DJ, Rose CR, Ryckmans T, Sun J, Theile JW, Torella R, Tseng E, Warmus JS. Storer RI, et al. Among authors: castle na. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4805-4811. doi: 10.1016/j.bmcl.2017.09.056. Epub 2017 Sep 28. Bioorg Med Chem Lett. 2017. PMID: 29029933
Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.
Alexandrou AJ, Brown AR, Chapman ML, Estacion M, Turner J, Mis MA, Wilbrey A, Payne EC, Gutteridge A, Cox PJ, Doyle R, Printzenhoff D, Lin Z, Marron BE, West C, Swain NA, Storer RI, Stupple PA, Castle NA, Hounshell JA, Rivara M, Randall A, Dib-Hajj SD, Krafte D, Waxman SG, Patel MK, Butt RP, Stevens EB. Alexandrou AJ, et al. Among authors: castle na. PLoS One. 2016 Apr 6;11(4):e0152405. doi: 10.1371/journal.pone.0152405. eCollection 2016. PLoS One. 2016. PMID: 27050761 Free PMC article.
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
McCormack K, Santos S, Chapman ML, Krafte DS, Marron BE, West CW, Krambis MJ, Antonio BM, Zellmer SG, Printzenhoff D, Padilla KM, Lin Z, Wagoner PK, Swain NA, Stupple PA, de Groot M, Butt RP, Castle NA. McCormack K, et al. Among authors: castle na. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2724-32. doi: 10.1073/pnas.1220844110. Epub 2013 Jul 1. Proc Natl Acad Sci U S A. 2013. PMID: 23818614 Free PMC article.
Aryl sulfonamido indane inhibitors of the Kv1.5 ion channel.
Gross MF, Beaudoin S, McNaughton-Smith G, Amato GS, Castle NA, Huang C, Zou A, Yu W. Gross MF, et al. Among authors: castle na. Bioorg Med Chem Lett. 2007 May 15;17(10):2849-53. doi: 10.1016/j.bmcl.2007.02.052. Epub 2007 Feb 27. Bioorg Med Chem Lett. 2007. PMID: 17350840
Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel.
Gross MF, Castle NA, Zou A, Wickenden AD, Yu W, Spear KL. Gross MF, et al. Among authors: castle na. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3063-6. doi: 10.1016/j.bmcl.2009.04.002. Epub 2009 Apr 8. Bioorg Med Chem Lett. 2009. PMID: 19398199
41 results