Barmada SJ - Search Results

1

CGG repeats trigger translational frameshifts that generate aggregation-prone chimeric proteins.

Wright SE, Rodriguez CM, Monroe J, Xing J, Krans A, Flores BN, Barsur V, Ivanova MI, Koutmou KS, Barmada SJ, Todd PK. Wright SE, et al. Among authors: barmada sj. Nucleic Acids Res. 2022 Aug 26;50(15):8674-8689. doi: 10.1093/nar/gkac626. Nucleic Acids Res. 2022. PMID: 35904811 Free PMC article.

2

Counter-regulation of RNA stability by UPF1 and TDP43.

Gomez N, Hsieh C, Li X, Dykstra M, Waksmacki J, Altheim C, Bechar Y, Klim J, Zaepfel B, Rothstein J, Tank EE, Barmada SJ. Gomez N, et al. Among authors: barmada sj. bioRxiv [Preprint]. 2024 Feb 15:2024.01.31.578310. doi: 10.1101/2024.01.31.578310. bioRxiv. 2024. PMID: 38352350 Free PMC article. Preprint.

3

Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity.

Flores BN, Dulchavsky ME, Krans A, Sawaya MR, Paulson HL, Todd PK, Barmada SJ, Ivanova MI. Flores BN, et al. Among authors: barmada sj. PLoS One. 2016 Oct 24;11(10):e0165084. doi: 10.1371/journal.pone.0165084. eCollection 2016. PLoS One. 2016. PMID: 27776165 Free PMC article.

4

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response.

Green KM, Glineburg MR, Kearse MG, Flores BN, Linsalata AE, Fedak SJ, Goldstrohm AC, Barmada SJ, Todd PK. Green KM, et al. Among authors: barmada sj. Nat Commun. 2017 Dec 8;8(1):2005. doi: 10.1038/s41467-017-02200-0. Nat Commun. 2017. PMID: 29222490 Free PMC article.

5

Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly.

Sharkey LM, Safren N, Pithadia AS, Gerson JE, Dulchavsky M, Fischer S, Patel R, Lantis G, Ashraf N, Kim JH, Meliki A, Minakawa EN, Barmada SJ, Ivanova MI, Paulson HL. Sharkey LM, et al. Among authors: barmada sj. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10495-E10504. doi: 10.1073/pnas.1810522115. Epub 2018 Oct 17. Proc Natl Acad Sci U S A. 2018. PMID: 30333186 Free PMC article.

6

An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration.

Flores BN, Li X, Malik AM, Martinez J, Beg AA, Barmada SJ. Flores BN, et al. Among authors: barmada sj. Cell Rep. 2019 Apr 23;27(4):1133-1150.e8. doi: 10.1016/j.celrep.2019.03.093. Cell Rep. 2019. PMID: 31018129 Free PMC article.

7

DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation.

Linsalata AE, He F, Malik AM, Glineburg MR, Green KM, Natla S, Flores BN, Krans A, Archbold HC, Fedak SJ, Barmada SJ, Todd PK. Linsalata AE, et al. Among authors: barmada sj. EMBO Rep. 2019 Sep;20(9):e47498. doi: 10.15252/embr.201847498. Epub 2019 Jul 25. EMBO Rep. 2019. PMID: 31347257 Free PMC article.

8

High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation.

Green KM, Sheth UJ, Flores BN, Wright SE, Sutter AB, Kearse MG, Barmada SJ, Ivanova MI, Todd PK. Green KM, et al. Among authors: barmada sj. J Biol Chem. 2019 Dec 6;294(49):18624-18638. doi: 10.1074/jbc.RA119.009951. Epub 2019 Oct 23. J Biol Chem. 2019. PMID: 31649034 Free PMC article.

9

A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis.

Rodriguez CM, Wright SE, Kearse MG, Haenfler JM, Flores BN, Liu Y, Ifrim MF, Glineburg MR, Krans A, Jafar-Nejad P, Sutton MA, Bassell GJ, Parent JM, Rigo F, Barmada SJ, Todd PK. Rodriguez CM, et al. Among authors: barmada sj. Nat Neurosci. 2020 Mar;23(3):386-397. doi: 10.1038/s41593-020-0590-1. Epub 2020 Feb 17. Nat Neurosci. 2020. PMID: 32066985 Free PMC article.

10

The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD.

He F, Flores BN, Krans A, Frazer M, Natla S, Niraula S, Adefioye O, Barmada SJ, Todd PK. He F, et al. Among authors: barmada sj. Acta Neuropathol Commun. 2020 Aug 4;8(1):122. doi: 10.1186/s40478-020-01002-8. Acta Neuropathol Commun. 2020. PMID: 32753055 Free PMC article.

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