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Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders.
Bryois J, Calini D, Macnair W, Foo L, Urich E, Ortmann W, Iglesias VA, Selvaraj S, Nutma E, Marzin M, Amor S, Williams A, Castelo-Branco G, Menon V, De Jager P, Malhotra D. Bryois J, et al. Among authors: williams a. Nat Neurosci. 2022 Aug;25(8):1104-1112. doi: 10.1038/s41593-022-01128-z. Epub 2022 Aug 1. Nat Neurosci. 2022. PMID: 35915177
Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis.
Falcão AM, van Bruggen D, Marques S, Meijer M, Jäkel S, Agirre E, Samudyata, Floriddia EM, Vanichkina DP, Ffrench-Constant C, Williams A, Guerreiro-Cacais AO, Castelo-Branco G. Falcão AM, et al. Among authors: williams a. Nat Med. 2018 Dec;24(12):1837-1844. doi: 10.1038/s41591-018-0236-y. Epub 2018 Nov 12. Nat Med. 2018. PMID: 30420755 Free PMC article.
Altered human oligodendrocyte heterogeneity in multiple sclerosis.
Jäkel S, Agirre E, Mendanha Falcão A, van Bruggen D, Lee KW, Knuesel I, Malhotra D, Ffrench-Constant C, Williams A, Castelo-Branco G. Jäkel S, et al. Among authors: williams a. Nature. 2019 Feb;566(7745):543-547. doi: 10.1038/s41586-019-0903-2. Epub 2019 Jan 23. Nature. 2019. PMID: 30747918 Free PMC article.
Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function.
Seeker LA, Bestard-Cuche N, Jäkel S, Kazakou NL, Bøstrand SMK, Wagstaff LJ, Cholewa-Waclaw J, Kilpatrick AM, Van Bruggen D, Kabbe M, Baldivia Pohl F, Moslehi Z, Henderson NC, Vallejos CA, La Manno G, Castelo-Branco G, Williams A. Seeker LA, et al. Among authors: williams a. Acta Neuropathol Commun. 2023 May 22;11(1):84. doi: 10.1186/s40478-023-01568-z. Acta Neuropathol Commun. 2023. PMID: 37217978 Free PMC article.
Retinoid X receptor gamma signaling accelerates CNS remyelination.
Huang JK, Jarjour AA, Nait Oumesmar B, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Baron-Van Evercooren A, Chambon P, Ffrench-Constant C, Franklin RJM. Huang JK, et al. Among authors: williams a. Nat Neurosci. 2011 Jan;14(1):45-53. doi: 10.1038/nn.2702. Epub 2010 Dec 5. Nat Neurosci. 2011. PMID: 21131950 Free PMC article.
Regulatory T cells promote myelin regeneration in the central nervous system.
Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC. Dombrowski Y, et al. Among authors: williams ac. Nat Neurosci. 2017 May;20(5):674-680. doi: 10.1038/nn.4528. Epub 2017 Mar 13. Nat Neurosci. 2017. PMID: 28288125 Free PMC article.
Central nervous system regeneration is driven by microglia necroptosis and repopulation.
Lloyd AF, Davies CL, Holloway RK, Labrak Y, Ireland G, Carradori D, Dillenburg A, Borger E, Soong D, Richardson JC, Kuhlmann T, Williams A, Pollard JW, des Rieux A, Priller J, Miron VE. Lloyd AF, et al. Among authors: williams a. Nat Neurosci. 2019 Jul;22(7):1046-1052. doi: 10.1038/s41593-019-0418-z. Epub 2019 Jun 10. Nat Neurosci. 2019. PMID: 31182869 Free PMC article.
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