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Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SW, Ioerger TR, Schnappinger D, Ehrt S. Xu W, et al. Among authors: dejesus ma. Antimicrob Agents Chemother. 2017 Nov 22;61(12):e01334-17. doi: 10.1128/AAC.01334-17. Print 2017 Dec. Antimicrob Agents Chemother. 2017. PMID: 28893793 Free PMC article.
Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis.
Bosch B, DeJesus MA, Poulton NC, Zhang W, Engelhart CA, Zaveri A, Lavalette S, Ruecker N, Trujillo C, Wallach JB, Li S, Ehrt S, Chait BT, Schnappinger D, Rock JM. Bosch B, et al. Among authors: dejesus ma. Cell. 2021 Aug 19;184(17):4579-4592.e24. doi: 10.1016/j.cell.2021.06.033. Epub 2021 Jul 22. Cell. 2021. PMID: 34297925 Free PMC article.
CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis.
Li S, Poulton NC, Chang JS, Azadian ZA, DeJesus MA, Ruecker N, Zimmerman MD, Eckartt KA, Bosch B, Engelhart CA, Sullivan DF, Gengenbacher M, Dartois VA, Schnappinger D, Rock JM. Li S, et al. Among authors: dejesus ma. Nat Microbiol. 2022 Jun;7(6):766-779. doi: 10.1038/s41564-022-01130-y. Epub 2022 May 30. Nat Microbiol. 2022. PMID: 35637331 Free PMC article.
A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens.
Choudhery S, DeJesus MA, Srinivasan A, Rock J, Schnappinger D, Ioerger TR. Choudhery S, et al. Among authors: dejesus ma. bioRxiv [Preprint]. 2024 Feb 7:2023.08.03.551759. doi: 10.1101/2023.08.03.551759. bioRxiv. 2024. Update in: PLoS Comput Biol. 2024 May 20;20(5):e1011408. doi: 10.1371/journal.pcbi.1011408 PMID: 37577548 Free PMC article. Updated. Preprint.
Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis.
Eckartt KA, Delbeau M, Munsamy-Govender V, DeJesus MA, Azadian ZA, Reddy AK, Chandanani J, Poulton NC, Quiñones-Garcia S, Bosch B, Landick R, Campbell EA, Rock JM. Eckartt KA, et al. Among authors: dejesus ma. Nature. 2024 Apr;628(8006):186-194. doi: 10.1038/s41586-024-07206-5. Epub 2024 Mar 20. Nature. 2024. PMID: 38509362 Free PMC article.
Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.
Korte J, Alber M, Trujillo CM, Syson K, Koliwer-Brandl H, Deenen R, Köhrer K, DeJesus MA, Hartman T, Jacobs WR Jr, Bornemann S, Ioerger TR, Ehrt S, Kalscheuer R. Korte J, et al. Among authors: dejesus ma. PLoS Pathog. 2016 Dec 9;12(12):e1006043. doi: 10.1371/journal.ppat.1006043. eCollection 2016 Dec. PLoS Pathog. 2016. PMID: 27936238 Free PMC article.
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