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A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth.
Yang F, Rodriguez-Blanco J, Long J, Swiderska-Syn M, Wynn DT, Li B, Shen C, Nayak A, Ban Y, Sun X, Suter RK, McCrea HJ, Capobianco AJ, Ayad NG, Robbins DJ. Yang F, et al. Mol Cancer Res. 2022 Nov 3;20(11):1598-1610. doi: 10.1158/1541-7786.MCR-22-0182. Mol Cancer Res. 2022. PMID: 35925047 Free PMC article.
Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity.
Singh S, Wang Z, Liang Fei D, Black KE, Goetz JA, Tokhunts R, Giambelli C, Rodriguez-Blanco J, Long J, Lee E, Briegel KJ, Bejarano PA, Dmitrovsky E, Capobianco AJ, Robbins DJ. Singh S, et al. Cancer Res. 2011 Jul 1;71(13):4454-63. doi: 10.1158/0008-5472.CAN-10-2313. Epub 2011 May 12. Cancer Res. 2011. PMID: 21565978 Free PMC article.
The hedgehog processing pathway is required for NSCLC growth and survival.
Rodriguez-Blanco J, Schilling NS, Tokhunts R, Giambelli C, Long J, Liang Fei D, Singh S, Black KE, Wang Z, Galimberti F, Bejarano PA, Elliot S, Glassberg MK, Nguyen DM, Lockwood WW, Lam WL, Dmitrovsky E, Capobianco AJ, Robbins DJ. Rodriguez-Blanco J, et al. Oncogene. 2013 May 2;32(18):2335-45. doi: 10.1038/onc.2012.243. Epub 2012 Jun 25. Oncogene. 2013. PMID: 22733134 Free PMC article.
Hedgehog signaling regulates bladder cancer growth and tumorigenicity.
Fei DL, Sanchez-Mejias A, Wang Z, Flaveny C, Long J, Singh S, Rodriguez-Blanco J, Tokhunts R, Giambelli C, Briegel KJ, Schulz WA, Gandolfi AJ, Karagas M, Zimmers TA, Jorda M, Bejarano P, Capobianco AJ, Robbins DJ. Fei DL, et al. Cancer Res. 2012 Sep 1;72(17):4449-58. doi: 10.1158/0008-5472.CAN-11-4123. Epub 2012 Jul 19. Cancer Res. 2012. PMID: 22815529 Free PMC article.
Pyrvinium attenuates Hedgehog signaling downstream of smoothened.
Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, Robbins DJ. Li B, et al. Cancer Res. 2014 Sep 1;74(17):4811-21. doi: 10.1158/0008-5472.CAN-14-0317. Epub 2014 Jul 3. Cancer Res. 2014. PMID: 24994715 Free PMC article.
Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.
Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. Li B, et al. Sci Signal. 2017 Jun 27;10(485):eaak9916. doi: 10.1126/scisignal.aak9916. Sci Signal. 2017. PMID: 28655862 Free PMC article.
Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma.
Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen DM, Ayad NG, Rai P, Capobianco AJ, Robbins DJ. Rodriguez-Blanco J, et al. Oncogene. 2017 Nov 9;36(45):6306-6314. doi: 10.1038/onc.2017.232. Epub 2017 Jul 17. Oncogene. 2017. PMID: 28714964 Free PMC article.
50 results