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The relationship between the epigenetic aging biomarker "grimage" and lung function in both the airway and blood of people living with HIV: An observational cohort study.
Hernández Cordero AI, Yang CX, Yang J, Li X, Horvath S, Shaipanich T, MacIsaac J, Lin D, McEwen L, Kobor MS, Guillemi S, Harris M, Lam W, Lam S, Obeidat M, Novak RM, Hudson F, Klinker H, Dharan N, Montaner J, Man SFP, Kunisaki K, Sin DD, Leung JM; INSIGHT START Pulmonary and Genomic Substudy Groups. Hernández Cordero AI, et al. Among authors: yang cx, yang j. EBioMedicine. 2022 Sep;83:104206. doi: 10.1016/j.ebiom.2022.104206. Epub 2022 Aug 6. EBioMedicine. 2022. PMID: 35944348 Free PMC article.
Decreased microbiome diversity in the HIV small airway epithelium.
Xu S, Tsai A, Sze MA, Vucic EA, Shaipanich T, Harris M, Guillemi S, Yang J, Sinha S, Nislow C, Montaner J, Lam W, Lam S, Sin DD, Paul Man SF, Leung JM. Xu S, et al. Among authors: yang j. Respir Res. 2018 Jul 27;19(1):140. doi: 10.1186/s12931-018-0835-7. Respir Res. 2018. PMID: 30053882 Free PMC article.
DNA methylation is associated with airflow obstruction in patients living with HIV.
Hernandez Cordero AI, Yang CX, Obeidat M, Yang J, MacIsaac J, McEwen L, Lin D, Kobor M, Novak R, Hudson F, Klinker H, Dharan N, Man SP, Sin DD, Kunisaki K, Leung J; INSIGHT START Pulmonary and Genomic Substudy Groups. Hernandez Cordero AI, et al. Among authors: yang cx, yang j. Thorax. 2021 May;76(5):448-455. doi: 10.1136/thoraxjnl-2020-215866. Epub 2020 Dec 18. Thorax. 2021. PMID: 33443234 Free PMC article. Clinical Trial.
Macrophages with reduced expressions of classical M1 and M2 surface markers in human bronchoalveolar lavage fluid exhibit pro-inflammatory gene signatures.
Takiguchi H, Yang CX, Yang CWT, Sahin B, Whalen BA, Milne S, Akata K, Yamasaki K, Yang JSW, Cheung CY, Vander Werff R, McNagny KM, Leitao Filho FS, Shaipanich T, van Eeden SF, Obeidat M, Leung JM, Sin DD. Takiguchi H, et al. Sci Rep. 2021 Apr 15;11(1):8282. doi: 10.1038/s41598-021-87720-y. Sci Rep. 2021. PMID: 33859282 Free PMC article.
Effects of Inhaled Corticosteroid/Long-Acting β2-Agonist Combination on the Airway Microbiome of Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Clinical Trial (DISARM).
Leitao Filho FS, Takiguchi H, Akata K, Ra SW, Moon JY, Kim HK, Cho Y, Yamasaki K, Milne S, Yang J, Yang CWT, Li X, Nislow C, van Eeden SF, Shaipanich T, Lam S, Leung JM, Sin DD. Leitao Filho FS, et al. Among authors: yang cwt, yang j. Am J Respir Crit Care Med. 2021 Nov 15;204(10):1143-1152. doi: 10.1164/rccm.202102-0289OC. Am J Respir Crit Care Med. 2021. PMID: 34464242 Clinical Trial.
Altered Polarization and Impaired Phagocytic Activity of Lung Macrophages in People With Human Immunodeficiency Virus and Chronic Obstructive Pulmonary Disease.
Akata K, Leung JM, Yamasaki K, Leitao Filho FS, Yang J, Xi Yang C, Takiguchi H, Shaipanich T, Sahin B, Whalen BA, Yang CWT, Sin DD, van Eeden SF. Akata K, et al. Among authors: yang cwt, yang j. J Infect Dis. 2022 Mar 2;225(5):862-867. doi: 10.1093/infdis/jiab506. J Infect Dis. 2022. PMID: 34610114
Ambient Air Pollution and Dysanapsis: Associations with Lung Function and Chronic Obstructive Pulmonary Disease in the Canadian Cohort Obstructive Lung Disease Study.
Bourbeau J, Doiron D, Biswas S, Smith BM, Benedetti A, Brook JR, Aaron SD, Chapman KR, Hernandez P, Maltais F, Marciniuk DD, O'Donnell D, Sin DD, Walker B, Dsilva L, Nadeau G, Coats V, Compton C, Miller BE, Tan WC; CanCOLD Collaborative Research Group and the Canadian Respiratory Research Network. Bourbeau J, et al. Am J Respir Crit Care Med. 2022 Jul 1;206(1):44-55. doi: 10.1164/rccm.202106-1439OC. Am J Respir Crit Care Med. 2022. PMID: 35380941 Free PMC article.
Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease.
Hernández Cordero AI, Yang CX, Yang J, Horvath S, Shaipanich T, MacIsaac J, Lin DTS, Kobor MS, Guillemi S, Harris M, Lam W, Lam S, Montaner J, Man SFP, Sin DD, Leung JM. Hernández Cordero AI, et al. Among authors: yang cx, yang j. Am J Respir Crit Care Med. 2022 Jul 15;206(2):150-160. doi: 10.1164/rccm.202106-1440OC. Am J Respir Crit Care Med. 2022. PMID: 35426765 Free PMC article.
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