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Page 1
A conformational switch controlling the toxicity of the prion protein.
Frontzek K, Bardelli M, Senatore A, Henzi A, Reimann RR, Bedir S, Marino M, Hussain R, Jurt S, Meisl G, Pedotti M, Mazzola F, Siligardi G, Zerbe O, Losa M, Knowles T, Lakkaraju A, Zhu C, Schwarz P, Hornemann S, Holt MG, Simonelli L, Varani L, Aguzzi A. Frontzek K, et al. Among authors: holt mg. Nat Struct Mol Biol. 2022 Aug;29(8):831-840. doi: 10.1038/s41594-022-00814-7. Epub 2022 Aug 10. Nat Struct Mol Biol. 2022. PMID: 35948768 Free PMC article.
AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model.
Marino M, Zhou L, Rincon MY, Callaerts-Vegh Z, Verhaert J, Wahis J, Creemers E, Yshii L, Wierda K, Saito T, Marneffe C, Voytyuk I, Wouters Y, Dewilde M, Duqué SI, Vincke C, Levites Y, Golde TE, Saido TC, Muyldermans S, Liston A, De Strooper B, Holt MG. Marino M, et al. Among authors: holt mg. EMBO Mol Med. 2022 Apr 7;14(4):e09824. doi: 10.15252/emmm.201809824. Epub 2022 Mar 30. EMBO Mol Med. 2022. PMID: 35352880 Free PMC article.
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation.
Yshii L, Pasciuto E, Bielefeld P, Mascali L, Lemaitre P, Marino M, Dooley J, Kouser L, Verschoren S, Lagou V, Kemps H, Gervois P, de Boer A, Burton OT, Wahis J, Verhaert J, Tareen SHK, Roca CP, Singh K, Whyte CE, Kerstens A, Callaerts-Vegh Z, Poovathingal S, Prezzemolo T, Wierda K, Dashwood A, Xie J, Van Wonterghem E, Creemers E, Aloulou M, Gsell W, Abiega O, Munck S, Vandenbroucke RE, Bronckaers A, Lemmens R, De Strooper B, Van Den Bosch L, Himmelreich U, Fitzsimons CP, Holt MG, Liston A. Yshii L, et al. Among authors: holt mg. Nat Immunol. 2022 Jun;23(6):878-891. doi: 10.1038/s41590-022-01208-z. Epub 2022 May 26. Nat Immunol. 2022. PMID: 35618831 Free PMC article.
Controlling synaptotagmin activity by electrostatic screening.
Park Y, Hernandez JM, van den Bogaart G, Ahmed S, Holt M, Riedel D, Jahn R. Park Y, et al. Nat Struct Mol Biol. 2012 Oct;19(10):991-7. doi: 10.1038/nsmb.2375. Epub 2012 Sep 2. Nat Struct Mol Biol. 2012. PMID: 22940675 Free PMC article.
One SNARE complex is sufficient for membrane fusion.
van den Bogaart G, Holt MG, Bunt G, Riedel D, Wouters FS, Jahn R. van den Bogaart G, et al. Among authors: holt mg. Nat Struct Mol Biol. 2010 Mar;17(3):358-64. doi: 10.1038/nsmb.1748. Epub 2010 Feb 7. Nat Struct Mol Biol. 2010. PMID: 20139985 Free PMC article.
Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation.
van den Bogaart G, Thutupalli S, Risselada JH, Meyenberg K, Holt M, Riedel D, Diederichsen U, Herminghaus S, Grubmüller H, Jahn R. van den Bogaart G, et al. Nat Struct Mol Biol. 2011 Jun 5;18(7):805-12. doi: 10.1038/nsmb.2061. Nat Struct Mol Biol. 2011. PMID: 21642968 Free PMC article.
Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice.
Bielefeld P, Martirosyan A, Martín-Suárez S, Apresyan A, Meerhoff GF, Pestana F, Poovathingal S, Reijner N, Koning W, Clement RA, Van der Veen I, Toledo EM, Polzer O, Durá I, Hovhannisyan S, Nilges BS, Bogdoll A, Kashikar ND, Lucassen PJ, Belgard TG, Encinas JM, Holt MG, Fitzsimons CP. Bielefeld P, et al. Among authors: holt mg. Nat Commun. 2024 Jun 18;15(1):5222. doi: 10.1038/s41467-024-49299-6. Nat Commun. 2024. PMID: 38890340 Free PMC article.
62 results