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Page 1
A conformational switch controlling the toxicity of the prion protein.
Frontzek K, Bardelli M, Senatore A, Henzi A, Reimann RR, Bedir S, Marino M, Hussain R, Jurt S, Meisl G, Pedotti M, Mazzola F, Siligardi G, Zerbe O, Losa M, Knowles T, Lakkaraju A, Zhu C, Schwarz P, Hornemann S, Holt MG, Simonelli L, Varani L, Aguzzi A. Frontzek K, et al. Among authors: reimann rr. Nat Struct Mol Biol. 2022 Aug;29(8):831-840. doi: 10.1038/s41594-022-00814-7. Epub 2022 Aug 10. Nat Struct Mol Biol. 2022. PMID: 35948768 Free PMC article.
The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.
Sonati T, Reimann RR, Falsig J, Baral PK, O'Connor T, Hornemann S, Yaganoglu S, Li B, Herrmann US, Wieland B, Swayampakula M, Rahman MH, Das D, Kav N, Riek R, Liberski PP, James MN, Aguzzi A. Sonati T, et al. Among authors: reimann rr. Nature. 2013 Sep 5;501(7465):102-6. doi: 10.1038/nature12402. Epub 2013 Jul 31. Nature. 2013. PMID: 23903654 Free article.
Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways.
Herrmann US, Sonati T, Falsig J, Reimann RR, Dametto P, O'Connor T, Li B, Lau A, Hornemann S, Sorce S, Wagner U, Sanoudou D, Aguzzi A. Herrmann US, et al. Among authors: reimann rr. PLoS Pathog. 2015 Feb 24;11(2):e1004662. doi: 10.1371/journal.ppat.1004662. eCollection 2015 Feb. PLoS Pathog. 2015. PMID: 25710374 Free PMC article.
Differential Toxicity of Antibodies to the Prion Protein.
Reimann RR, Sonati T, Hornemann S, Herrmann US, Arand M, Hawke S, Aguzzi A. Reimann RR, et al. PLoS Pathog. 2016 Jan 28;12(1):e1005401. doi: 10.1371/journal.ppat.1005401. eCollection 2016 Jan. PLoS Pathog. 2016. PMID: 26821311 Free PMC article.
Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier.
Keller A, Nuvolone M, Abakumova I, Chincisan A, Reimann R, Avar M, Heinzer D, Hornemann S, Wagner J, Kirschenbaum D, Voigt FF, Zhu C, Regli L, Helmchen F, Aguzzi A. Keller A, et al. PLoS Pathog. 2018 Nov 29;14(11):e1007424. doi: 10.1371/journal.ppat.1007424. eCollection 2018 Nov. PLoS Pathog. 2018. PMID: 30496289 Free PMC article.
Inflammatory olfactory neuropathy in two patients with COVID-19.
Kirschenbaum D, Imbach LL, Ulrich S, Rushing EJ, Keller E, Reimann RR, Frauenknecht KBM, Lichtblau M, Witt M, Hummel T, Steiger P, Aguzzi A, Frontzek K. Kirschenbaum D, et al. Among authors: reimann rr. Lancet. 2020 Jul 18;396(10245):166. doi: 10.1016/S0140-6736(20)31525-7. Epub 2020 Jul 10. Lancet. 2020. PMID: 32659210 Free PMC article. No abstract available.
Protective anti-prion antibodies in human immunoglobulin repertoires.
Senatore A, Frontzek K, Emmenegger M, Chincisan A, Losa M, Reimann R, Horny G, Guo J, Fels S, Sorce S, Zhu C, George N, Ewert S, Pietzonka T, Hornemann S, Aguzzi A. Senatore A, et al. EMBO Mol Med. 2020 Sep 7;12(9):e12739. doi: 10.15252/emmm.202012739. Epub 2020 Aug 10. EMBO Mol Med. 2020. PMID: 32776637 Free PMC article.
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