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Page 1
Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.
A M Subbaiah M, Subramani L, Ramar T, Desai S, Sinha S, Mandlekar S, Kadow JF, Jenkins S, Krystal M, Subramanian M, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Meanwell NA. A M Subbaiah M, et al. Among authors: arla r. J Med Chem. 2022 Aug 25;65(16):11150-11176. doi: 10.1021/acs.jmedchem.2c00632. Epub 2022 Aug 11. J Med Chem. 2022. PMID: 35952307
Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.
A M Subbaiah M, Mandlekar S, Desikan S, Ramar T, Subramani L, Annadurai M, Desai SD, Sinha S, Jenkins SM, Krystal MR, Subramanian M, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Singh S, Sinha J, Thakur M, Kadow JF, Meanwell NA. A M Subbaiah M, et al. Among authors: arla r. J Med Chem. 2019 Apr 11;62(7):3553-3574. doi: 10.1021/acs.jmedchem.9b00002. Epub 2019 Apr 2. J Med Chem. 2019. PMID: 30938524
(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration.
Subbaiah MAM, Ramar T, Subramani L, Desai SD, Sinha S, Mandlekar S, Jenkins SM, Krystal MR, Subramanian M, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Kadow JF, Meanwell NA. Subbaiah MAM, et al. Among authors: arla r. Eur J Med Chem. 2020 Dec 1;207:112749. doi: 10.1016/j.ejmech.2020.112749. Epub 2020 Aug 21. Eur J Med Chem. 2020. PMID: 33065417
Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.
Subbaiah MAM, Meanwell NA, Kadow JF, Subramani L, Annadurai M, Ramar T, Desai SD, Sinha S, Subramanian M, Mandlekar S, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Jenkins SM, Krystal MR, Wang C, Sarabu R. Subbaiah MAM, et al. Among authors: arla r. J Med Chem. 2018 May 10;61(9):4176-4188. doi: 10.1021/acs.jmedchem.8b00277. Epub 2018 Apr 25. J Med Chem. 2018. PMID: 29693401
Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models.
Holenarsipur VK, Gaud N, Sinha J, Sivaprasad S, Bhutani P, Subramanian M, Singh SP, Arla R, Paruchury S, Sharma T, Marathe P, Mandlekar S. Holenarsipur VK, et al. Among authors: arla r. Biopharm Drug Dispos. 2015 Sep;36(6):385-397. doi: 10.1002/bdd.1950. Epub 2015 May 4. Biopharm Drug Dispos. 2015. PMID: 25832562
Characterization of recombinantly expressed rat and monkey intestinal alkaline phosphatases: in vitro studies and in vivo correlations.
Subramanian M, Paruchury S, Singh Gautam S, Pratap Singh S, Arla R, Pahwa S, Jana S, Katnapally P, Yoganand V, Lakshmaiah B, Mazumder Tagore D, Ghosh K, Marathe P, Mandlekar S. Subramanian M, et al. Among authors: arla r. Drug Metab Dispos. 2013 Jul;41(7):1425-32. doi: 10.1124/dmd.113.051987. Epub 2013 Apr 30. Drug Metab Dispos. 2013. PMID: 23633529
Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation.
Thappali SR, Varanasi K, Veeraraghavan S, Arla R, Chennupati S, Rajamanickam M, Vakkalanka S, Khagga M. Thappali SR, et al. Among authors: arla r. Sci Pharm. 2012 Jul-Sep;80(3):633-46. doi: 10.3797/scipharm.1205-09. Epub 2012 Jun 18. Sci Pharm. 2012. PMID: 23008811 Free PMC article.