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Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.
A M Subbaiah M, Subramani L, Ramar T, Desai S, Sinha S, Mandlekar S, Kadow JF, Jenkins S, Krystal M, Subramanian M, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Meanwell NA. A M Subbaiah M, et al. Among authors: desai s. J Med Chem. 2022 Aug 25;65(16):11150-11176. doi: 10.1021/acs.jmedchem.2c00632. Epub 2022 Aug 11. J Med Chem. 2022. PMID: 35952307
Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.
Subbaiah MAM, Meanwell NA, Kadow JF, Subramani L, Annadurai M, Ramar T, Desai SD, Sinha S, Subramanian M, Mandlekar S, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Jenkins SM, Krystal MR, Wang C, Sarabu R. Subbaiah MAM, et al. Among authors: desai sd. J Med Chem. 2018 May 10;61(9):4176-4188. doi: 10.1021/acs.jmedchem.8b00277. Epub 2018 Apr 25. J Med Chem. 2018. PMID: 29693401
Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.
A M Subbaiah M, Mandlekar S, Desikan S, Ramar T, Subramani L, Annadurai M, Desai SD, Sinha S, Jenkins SM, Krystal MR, Subramanian M, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Singh S, Sinha J, Thakur M, Kadow JF, Meanwell NA. A M Subbaiah M, et al. Among authors: desai sd. J Med Chem. 2019 Apr 11;62(7):3553-3574. doi: 10.1021/acs.jmedchem.9b00002. Epub 2019 Apr 2. J Med Chem. 2019. PMID: 30938524
(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration.
Subbaiah MAM, Ramar T, Subramani L, Desai SD, Sinha S, Mandlekar S, Jenkins SM, Krystal MR, Subramanian M, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Kadow JF, Meanwell NA. Subbaiah MAM, et al. Among authors: desai sd. Eur J Med Chem. 2020 Dec 1;207:112749. doi: 10.1016/j.ejmech.2020.112749. Epub 2020 Aug 21. Eur J Med Chem. 2020. PMID: 33065417
Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
Sun LQ, Mull E, D'Andrea S, Zheng B, Hiebert S, Gillis E, Bowsher M, Kandhasamy S, Baratam VR, Puttaswamy S, Pulicharla N, Vishwakrishnan S, Reddy S, Trivedi R, Sinha S, Sivaprasad S, Rao A, Desai S, Ghosh K, Anumula R, Kumar A, Rajamani R, Wang YK, Fang H, Mathur A, Rampulla R, Zvyaga TA, Mosure K, Jenkins S, Falk P, Tagore DM, Chen C, Rendunchintala K, Loy J, Meanwell NA, McPhee F, Scola PM. Sun LQ, et al. Among authors: desai s. J Med Chem. 2020 Dec 10;63(23):14740-14760. doi: 10.1021/acs.jmedchem.0c01296. Epub 2020 Nov 23. J Med Chem. 2020. PMID: 33226226
Papillary Carcinoma Within a Thyroglossal Duct Cyst.
Shah VS, Vaidya RU, Desai SC, Gajjar JP. Shah VS, et al. Among authors: desai sc. Cureus. 2024 Nov 25;16(11):e74407. doi: 10.7759/cureus.74407. eCollection 2024 Nov. Cureus. 2024. PMID: 39723318 Free PMC article.
Geo-Spatial Analysis of Acute Ischemic Stroke Reperfusion Treatment in India: An Assessment of Distribution and Access to Centers.
Asif K, Mitra A, Ortega-Gutierrez S, Herial NA, Desai SM, Jadhav A, Al-Mufti F, Roy A, Singh R, Brown G, Sarraj A, Jose A, Alurkar A, Karapurkar A, Sharma A, Gupta V, Goel G, Khurana D, Das B, Roy J, Das D, Kumar R, Kuruttukulam G, Pradeep Kumar VG, Srivastava PM, Pandian JD, Huded V, Yavagal D, Soman B, Sylaja PN. Asif K, et al. Among authors: desai sm. Int J Stroke. 2024 Dec 24:17474930241312598. doi: 10.1177/17474930241312598. Online ahead of print. Int J Stroke. 2024. PMID: 39719435
Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer.
Cutty SJ, Hughes FA, Ortega-Prieto P, Desai S, Thomas P, Fets LV, Secrier M, Barr AR. Cutty SJ, et al. Among authors: desai s. Br J Cancer. 2024 Dec 20. doi: 10.1038/s41416-024-02928-9. Online ahead of print. Br J Cancer. 2024. PMID: 39706988
3,921 results