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Page 1
Immunoprophylaxis using polypeptide chimera vaccines plus adjuvant system promote Th1 response controlling the spleen parasitism in hamster model of visceral leishmaniasis.
Gusmão MR, Ostolin TLVDP, Carvalho LM, Costa AFP, Moreira GJL, Cardoso JMO, Aguiar-Soares RDO, Reis AB, de Brito RCF, Roatt BM. Gusmão MR, et al. Among authors: moreira gjl. Vaccine. 2022 Sep 2;40(37):5494-5503. doi: 10.1016/j.vaccine.2022.08.005. Epub 2022 Aug 10. Vaccine. 2022. PMID: 35963820 Free article.
LBMPL Vaccine Therapy Induces Progressive Organization of the Spleen Microarchitecture, Improved Th1 Adaptative Immune Response and Control of Parasitism in Leishmania infantum Naturally Infected Dogs.
Roatt BM, de Oliveira Cardoso JM, Reis LES, Moreira GJL, Gonçalves LC, de Souza Marques F, das Dores Moreira N, de Abreu Vieira PM, de Oliveira Aguiar-Soares RD, Giunchetti RC, Reis AB. Roatt BM, et al. Among authors: moreira gjl. Pathogens. 2022 Aug 26;11(9):974. doi: 10.3390/pathogens11090974. Pathogens. 2022. PMID: 36145406 Free PMC article.
Preclinical evaluation of immunogenicity and protective efficacy of a recombinant chimeric protein vaccine against visceral leishmaniasis.
Lage DP, Vale DL, Maia FAG, Martins VT, Silva MGP, Galvani NC, Cardoso MM, Moreira GJL, Sombrio EM, Freitas CS, Pimenta BL, Falcão KOM, Dias SSG, Bandeira RS, Pereira IAG, Tavares GSV, Teixeira AL, Chávez-Fumagalli MA, Roatt BM, Machado-de-Ávila RA, Coelho EAF. Lage DP, et al. Among authors: moreira gjl. Parasitology. 2024 Nov 28:1-13. doi: 10.1017/S0031182024001240. Online ahead of print. Parasitology. 2024. PMID: 39604215
Immunization with recombinant LiHyp1 protein plus adjuvant is protective against tegumentary leishmaniasis.
Jesus MM, Lage DP, Vale DL, Freitas CS, Pimenta BL, Moreira GJL, Ramos FF, Pereira IAG, Bandeira RS, Ludolf F, Tavares GSV, Galdino AS, Duarte MC, Menezes-Souza D, Chávez-Fumagalli MA, Teixeira AL, Gonçalves DU, Roatt BM, Christodoulides M, Martins VT, Coelho EAF. Jesus MM, et al. Among authors: moreira gjl. Parasitol Res. 2023 Dec;122(12):2917-2931. doi: 10.1007/s00436-023-07981-6. Epub 2023 Sep 28. Parasitol Res. 2023. PMID: 37768367
The association between rLiHyp1 protein plus adjuvant and amphotericin B is an effective immunotherapy against visceral leishmaniasis in mice.
Lage DP, Martins VT, Vale DL, Freitas CS, Pimenta BL, Moreira GJL, Ramos FF, Pereira IAG, Bandeira RS, de Jesus MM, Ludolf F, Tavares GSV, Chávez-Fumagalli MA, Roatt BM, Christodoulides M, Coelho EAF. Lage DP, et al. Among authors: moreira gjl. Acta Trop. 2023 Oct;246:106986. doi: 10.1016/j.actatropica.2023.106986. Epub 2023 Jul 14. Acta Trop. 2023. PMID: 37453579
Efficacy of an Immunotherapy Combining Immunogenic Chimeric Protein Plus Adjuvant and Amphotericin B against Murine Visceral Leishmaniasis.
Vale DL, Freitas CS, Martins VT, Moreira GJL, Machado AS, Ramos FF, Pereira IAG, Bandeira RS, de Jesus MM, Tavares GSV, Ludolf F, Chávez-Fumagalli MA, Galdino AS, Fujiwara RT, Bueno LL, Roatt BM, Christodoulides M, Coelho EAF, Lage DP. Vale DL, et al. Among authors: moreira gjl. Biology (Basel). 2023 Jun 13;12(6):851. doi: 10.3390/biology12060851. Biology (Basel). 2023. PMID: 37372136 Free PMC article.