Li Q - Search Results

1

N-Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer's Disease.

Du C, Wang L, Guan Q, Yang H, Chen T, Liu Y, Li Q, Lyu W, Lu X, Chen Y, Liu Y, Liu H, Feng F, Liu W, Liu Z, Li W, Chen Y, Sun H. Du C, et al. Among authors: li w, li q. J Med Chem. 2022 Aug 25;65(16):11365-11387. doi: 10.1021/acs.jmedchem.2c00944. Epub 2022 Aug 15. J Med Chem. 2022. PMID: 35969197

2

Small molecule KDM4s inhibitors as anti-cancer agents.

Lin H, Li Q, Li Q, Zhu J, Gu K, Jiang X, Hu Q, Feng F, Qu W, Chen Y, Sun H. Lin H, et al. Among authors: li q. J Enzyme Inhib Med Chem. 2018 Dec;33(1):777-793. doi: 10.1080/14756366.2018.1455676. J Enzyme Inhib Med Chem. 2018. PMID: 29651880 Free PMC article.

3

Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation.

Lu X, Yang H, Li Q, Chen Y, Li Q, Zhou Y, Feng F, Liu W, Guo Q, Sun H. Lu X, et al. Among authors: li q. Bioorg Chem. 2019 Apr;85:117-127. doi: 10.1016/j.bioorg.2018.12.023. Epub 2018 Dec 21. Bioorg Chem. 2019. PMID: 30605885

4

Discovery, molecular dynamic simulation and biological evaluation of structurally diverse cholinesterase inhibitors with new scaffold through shape-based pharmacophore virtual screening.

Yang H, Du C, Li Q, Chen T, Lu X, Li Q, Feng F, Chen Y, Liu W, Sun H. Yang H, et al. Among authors: li q. Bioorg Chem. 2019 Nov;92:103294. doi: 10.1016/j.bioorg.2019.103294. Epub 2019 Sep 19. Bioorg Chem. 2019. PMID: 31557623

5

Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors.

Mo J, Yang H, Chen T, Li Q, Lin H, Feng F, Liu W, Qu W, Guo Q, Chi H, Chen Y, Sun H. Mo J, et al. Among authors: li q. Bioorg Chem. 2019 Dec;93:103310. doi: 10.1016/j.bioorg.2019.103310. Epub 2019 Sep 23. Bioorg Chem. 2019. PMID: 31586704

6

Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases.

Li Q, Xing S, Chen Y, Liao Q, Li Q, Liu Y, He S, Feng F, Chen Y, Zhang J, Liu W, Guo Q, Sun Y, Sun H. Li Q, et al. Eur J Med Chem. 2020 Jan 1;185:111862. doi: 10.1016/j.ejmech.2019.111862. Epub 2019 Nov 8. Eur J Med Chem. 2020. PMID: 31735576 Review.

7

Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer's Diseases.

Guo Y, Yang H, Huang Z, Tian S, Li Q, Du C, Chen T, Liu Y, Sun H, Liu Z. Guo Y, et al. Among authors: li q. Molecules. 2020 Jan 23;25(3):489. doi: 10.3390/molecules25030489. Molecules. 2020. PMID: 31979317 Free PMC article.

8

p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators.

Chen Y, Li Q, Li Q, Xing S, Liu Y, Liu Y, Chen Y, Liu W, Feng F, Sun H. Chen Y, et al. Among authors: li q. J Med Chem. 2020 Sep 24;63(18):10135-10157. doi: 10.1021/acs.jmedchem.9b02038. Epub 2020 May 5. J Med Chem. 2020. PMID: 32324396

9

Discovery of a Selective 6-Hydroxy-1, 4-Diazepan-2-one Containing Butyrylcholinesterase Inhibitor by Virtual Screening and MM-GBSA Rescoring.

Zhou Y, Hu Y, Lu X, Yang H, Li Q, Du C, Chen Y, Hong KH, Sun H. Zhou Y, et al. Among authors: li q. Dose Response. 2020 Jun 29;18(2):1559325820938526. doi: 10.1177/1559325820938526. eCollection 2020 Apr-Jun. Dose Response. 2020. PMID: 32636723 Free PMC article.

10

Discovery and Biological Evaluation of a Novel Highly Potent Selective Butyrylcholinsterase Inhibitor.

Li Q, Xing S, Chen Y, Liao Q, Xiong B, He S, Lu W, Liu Y, Yang H, Li Q, Feng F, Liu W, Chen Y, Sun H. Li Q, et al. J Med Chem. 2020 Sep 10;63(17):10030-10044. doi: 10.1021/acs.jmedchem.0c01129. Epub 2020 Aug 13. J Med Chem. 2020. PMID: 32787113

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