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Page 1
Selective Polyprotein Processing Determines Norovirus Sensitivity to Trim7.
Sullender ME, Pierce LR, Annaswamy Srinivas M, Crockett SL, Dunlap BF, Rodgers R, Schriefer LA, Kennedy EA, Stewart BM, Doench JG, Baldridge MT, Orchard RC. Sullender ME, et al. Among authors: orchard rc. J Virol. 2022 Sep 14;96(17):e0070722. doi: 10.1128/jvi.00707-22. Epub 2022 Aug 16. J Virol. 2022. PMID: 35972292 Free PMC article.
Discovery of a proteinaceous cellular receptor for a norovirus.
Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW. Orchard RC, et al. Science. 2016 Aug 26;353(6302):933-6. doi: 10.1126/science.aaf1220. Epub 2016 Aug 18. Science. 2016. PMID: 27540007 Free PMC article.
Tropism for tuft cells determines immune promotion of norovirus pathogenesis.
Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, Virgin HW. Wilen CB, et al. Among authors: orchard rc. Science. 2018 Apr 13;360(6385):204-208. doi: 10.1126/science.aar3799. Science. 2018. PMID: 29650672 Free PMC article.
A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis.
Lee S, Liu H, Wilen CB, Sychev ZE, Desai C, Hykes BL Jr, Orchard RC, McCune BT, Kim KW, Nice TJ, Handley SA, Baldridge MT, Amarasinghe GK, Virgin HW. Lee S, et al. Among authors: orchard rc. Cell Host Microbe. 2019 Jun 12;25(6):845-857.e5. doi: 10.1016/j.chom.2019.04.005. Epub 2019 May 23. Cell Host Microbe. 2019. PMID: 31130511 Free PMC article.
Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock.
Orvedahl A, McAllaster MR, Sansone A, Dunlap BF, Desai C, Wang YT, Balce DR, Luke CJ, Lee S, Orchard RC, Artyomov MN, Handley SA, Doench JG, Silverman GA, Virgin HW. Orvedahl A, et al. Among authors: orchard rc. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16497-16506. doi: 10.1073/pnas.1822157116. Epub 2019 Jul 25. Proc Natl Acad Sci U S A. 2019. PMID: 31346084 Free PMC article.
Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes.
Wang YT, Zaitsev K, Lu Q, Li S, Schaiff WT, Kim KW, Droit L, Wilen CB, Desai C, Balce DR, Orchard RC, Orvedahl A, Park S, Kreamalmeyer D, Handley SA, Pfeifer JD, Baldridge MT, Artyomov MN, Stallings CL, Virgin HW. Wang YT, et al. Among authors: orchard rc. Nat Microbiol. 2020 Feb;5(2):272-281. doi: 10.1038/s41564-019-0633-0. Epub 2020 Jan 20. Nat Microbiol. 2020. PMID: 31959973 Free PMC article.
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