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Page 1
Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling.
Rosenberg N, Van Haele M, Lanton T, Brashi N, Bromberg Z, Adler H, Giladi H, Peled A, Goldenberg DS, Axelrod JH, Simerzin A, Chai C, Paldor M, Markezana A, Yaish D, Shemulian Z, Gross D, Barnoy S, Gefen M, Amran O, Claerhout S, Fernández-Vaquero M, García-Beccaria M, Heide D, Shoshkes-Carmel M, Schmidt Arras D, Elgavish S, Nevo Y, Benyamini H, Tirnitz-Parker JEE, Sanchez A, Herrera B, Safadi R, Kaestner KH, Rose-John S, Roskams T, Heikenwalder M, Galun E. Rosenberg N, et al. Among authors: heide d. J Hepatol. 2022 Dec;77(6):1631-1641. doi: 10.1016/j.jhep.2022.07.029. Epub 2022 Aug 18. J Hepatol. 2022. PMID: 35988690
Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection.
Faure-Dupuy S, Delphin M, Aillot L, Dimier L, Lebossé F, Fresquet J, Parent R, Matter MS, Rivoire M, Bendriss-Vermare N, Salvetti A, Heide D, Flores L, Klumpp K, Lam A, Zoulim F, Heikenwälder M, Durantel D, Lucifora J. Faure-Dupuy S, et al. Among authors: heide d. J Hepatol. 2019 Dec;71(6):1086-1098. doi: 10.1016/j.jhep.2019.06.032. Epub 2019 Jul 23. J Hepatol. 2019. PMID: 31349000 Free article.
Hypoxia-Inducible Factor 1 Alpha-Mediated RelB/APOBEC3B Down-regulation Allows Hepatitis B Virus Persistence.
Riedl T, Faure-Dupuy S, Rolland M, Schuehle S, Hizir Z, Calderazzo S, Zhuang X, Wettengel J, Lopez MA, Barnault R, Mirakaj V, Prokosch S, Heide D, Leuchtenberger C, Schneider M, Heßling B, Stottmeier B, Wessbecher IM, Schirmacher P, McKeating JA, Protzer U, Durantel D, Lucifora J, Dejardin E, Heikenwalder M. Riedl T, et al. Among authors: heide d. Hepatology. 2021 Oct;74(4):1766-1781. doi: 10.1002/hep.31902. Epub 2021 Aug 15. Hepatology. 2021. PMID: 33991110 Free PMC article.
Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation.
Colasanti O, Burm R, Huang HE, Riedl T, Traut J, Gillich N, Li TF, Corneillie L, Faure-Dupuy S, Grünvogel O, Heide D, Lee JY, Tran CS, Merle U, Chironna M, Vondran FFW, Esser-Nobis K, Binder M, Bartenschlager R, Heikenwälder M, Meuleman P, Lohmann V. Colasanti O, et al. Among authors: heide d. J Hepatol. 2023 Sep;79(3):645-656. doi: 10.1016/j.jhep.2023.04.023. Epub 2023 Apr 29. J Hepatol. 2023. PMID: 37121436 Free article.
Corrigendum to "Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation" [J Hepatol (2023) 645-656].
Colasanti O, Burm R, Huang HE, Riedl T, Traut J, Gillich N, Li TF, Corneillie L, Faure-Dupuy S, Grünvogel O, Heide D, Lee JY, Tran CS, Merle U, Chironna M, Vondran FFW, Esser-Nobis K, Binder M, Bartenschlager R, Heikenwälder M, Meuleman P, Lohmann V. Colasanti O, et al. Among authors: heide d. J Hepatol. 2024 Jan;80(1):171-172. doi: 10.1016/j.jhep.2023.11.007. Epub 2023 Nov 30. J Hepatol. 2024. PMID: 38040570 Free article. No abstract available.
Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice.
Funk MC, Gleixner JG, Heigwer F, Vonficht D, Valentini E, Aydin Z, Tonin E, Del Prete S, Mahara S, Throm Y, Hetzer J, Heide D, Stegle O, Odom DT, Feldmann A, Haas S, Heikenwalder M, Boutros M. Funk MC, et al. Among authors: heide d. Dev Cell. 2023 Dec 18;58(24):2914-2929.e7. doi: 10.1016/j.devcel.2023.11.013. Dev Cell. 2023. PMID: 38113852 Free article.
Lymphotoxin beta-activated LTBR/NIK/RELB axis drives proliferation in cholangiocarcinoma.
Xu K, Kessler A, Nichetti F, Hoffmeister-Wittmann P, Scherr AL, Nader L, Kelmendi E, Schmitt N, Schwab M, García-Beccaria M, Sobol B, Nieto OA, Isele H, Gärtner U, Vaquero-Siguero N, Volk J, Korell F, Mock A, Heide D, Ramadori P, Lenoir B, Albrecht T, Hüllein J, Jäger D, Fröhling S, Springfeld C, Jackstadt R, Heikenwälder M, Dill MT, Roessler S, Goeppert B, Köhler BC. Xu K, et al. Among authors: heide d. Liver Int. 2024 Nov;44(11):2950-2963. doi: 10.1111/liv.16069. Epub 2024 Aug 20. Liver Int. 2024. PMID: 39164890 Free article.
Targeting the liver clock improves fibrosis by restoring TGF-β signaling.
Crouchet E, Dachraoui M, Jühling F, Roehlen N, Oudot MA, Durand SC, Ponsolles C, Gadenne C, Meiss-Heydmann L, Moehlin J, Martin R, Brignon N, Del Zompo F, Teraoka Y, Aikata H, Abe-Chayama H, Chayama K, Saviano A, Heide D, Onea M, Geyer L, Wolf T, Felli E, Pessaux P, Heikenwälder M, Chambon P, Schuster C, Lupberger J, Mukherji A, Baumert TF. Crouchet E, et al. Among authors: heide d. J Hepatol. 2025 Jan;82(1):120-133. doi: 10.1016/j.jhep.2024.07.034. Epub 2024 Aug 22. J Hepatol. 2025. PMID: 39173955
Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome.
Gallage S, Irvine EE, Barragan Avila JE, Reen V, Pedroni SMA, Duran I, Ranvir V, Khadayate S, Pombo J, Brookes S, Heide D, Dharmalingham G, Choudhury AI, Singh I, Herranz N, Vernia S, Heikenwalder M, Gil J, Withers DJ. Gallage S, et al. Among authors: heide d. Nat Aging. 2024 Nov;4(11):1544-1561. doi: 10.1038/s43587-024-00695-z. Epub 2024 Aug 29. Nat Aging. 2024. PMID: 39210150 Free PMC article.
Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.
Elßner C, Goeppert B, Longerich T, Scherr AL, Stindt J, Nanduri LK, Rupp C, Kather JN, Schmitt N, Kautz N, Breuhahn K, Ismail L, Heide D, Hetzer J, García-Beccaria M, Hövelmeyer N, Waisman A, Urbanik T, Mueller S, Gdynia G, Banales JM, Roessler S, Schirmacher P, Jäger D, Schölch S, Keitel V, Heikenwalder M, Schulze-Bergkamen H, Köhler BC. Elßner C, et al. Among authors: heide d. Gastroenterology. 2019 Mar;156(4):1190-1205.e14. doi: 10.1053/j.gastro.2018.11.018. Epub 2018 Nov 13. Gastroenterology. 2019. PMID: 30445013
140 results