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Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
Shin HR, Citron YR, Wang L, Tribouillard L, Goul CS, Stipp R, Sugasawa Y, Jain A, Samson N, Lim CY, Davis OB, Castaneda-Carpio D, Qian M, Nomura DK, Perera RM, Park E, Covey DF, Laplante M, Evers AS, Zoncu R. Shin HR, et al. Among authors: qian m. Science. 2022 Sep 16;377(6612):1290-1298. doi: 10.1126/science.abg6621. Epub 2022 Aug 25. Science. 2022. PMID: 36007018 Free PMC article.
Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.
Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF, Mennerick S, Covey DF. Qian M, et al. J Med Chem. 2014 Jan 9;57(1):171-90. doi: 10.1021/jm401577c. Epub 2013 Dec 24. J Med Chem. 2014. PMID: 24328079 Free PMC article.
Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABA(A) Receptors.
Chakrabarti S, Qian M, Krishnan K, Covey DF, Mennerick S, Akk G. Chakrabarti S, et al. Among authors: qian m. Mol Pharmacol. 2016 Apr;89(4):399-406. doi: 10.1124/mol.115.102202. Epub 2016 Jan 14. Mol Pharmacol. 2016. PMID: 26769414 Free PMC article.
Multiple functional neurosteroid binding sites on GABAA receptors.
Chen ZW, Bracamontes JR, Budelier MM, Germann AL, Shin DJ, Kathiresan K, Qian MX, Manion B, Cheng WWL, Reichert DE, Akk G, Covey DF, Evers AS. Chen ZW, et al. Among authors: qian mx. PLoS Biol. 2019 Mar 7;17(3):e3000157. doi: 10.1371/journal.pbio.3000157. eCollection 2019 Mar. PLoS Biol. 2019. PMID: 30845142 Free PMC article.
2,224 results