Ubah O - Search Results

1

Enhancing the Transdermal Delivery of 'Next Generation' Variable New Antigen Receptors Using Microarray Patch Technology: a Proof-of-Concept Study.

Hutton ARJ, Ubah O, Barelle C, Donnelly RF. Hutton ARJ, et al. Among authors: ubah o. J Pharm Sci. 2022 Dec;111(12):3362-3376. doi: 10.1016/j.xphs.2022.08.027. Epub 2022 Aug 26. J Pharm Sci. 2022. PMID: 36037879 Free article.

2

Phage Display Derived IgNAR V Region Binding Domains for Therapeutic Development.

Ubah OC, Barelle CJ, Buschhaus MJ, Porter AJ. Ubah OC, et al. Curr Pharm Des. 2016;22(43):6519-6526. doi: 10.2174/1381612822666160907091708. Curr Pharm Des. 2016. PMID: 27604606 Review.

3

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model.

Ubah OC, Steven J, Porter AJ, Barelle CJ. Ubah OC, et al. Front Immunol. 2019 Mar 22;10:526. doi: 10.3389/fimmu.2019.00526. eCollection 2019. Front Immunol. 2019. PMID: 30967865 Free PMC article.

4

In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development.

Ubah OC, Porter AJ, Barelle CJ. Ubah OC, et al. J Immunol Res. 2020 Feb 3;2020:7283239. doi: 10.1155/2020/7283239. eCollection 2020. J Immunol Res. 2020. PMID: 32090129 Free PMC article.

5

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography.

Ubah OC, Lake EW, Gunaratne GS, Gallant JP, Fernie M, Robertson AJ, Marchant JS, Bold TD, Langlois RA, Matchett WE, Thiede JM, Shi K, Yin L, Moeller NH, Banerjee S, Ferguson L, Kovaleva M, Porter AJ, Aihara H, LeBeau AM, Barelle CJ. Ubah OC, et al. Nat Commun. 2021 Dec 16;12(1):7325. doi: 10.1038/s41467-021-27611-y. Nat Commun. 2021. PMID: 34916516 Free PMC article.

6

Overview, Generation, and Significance of Variable New Antigen Receptors (VNARs) as a Platform for Drug and Diagnostic Development.

Pandey SS, Kovaleva M, Barelle CJ, Ubah OC. Pandey SS, et al. Among authors: ubah oc. Methods Mol Biol. 2022;2446:19-33. doi: 10.1007/978-1-0716-2075-5_2. Methods Mol Biol. 2022. PMID: 35157267

7

Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development.

Ubah OC, Steven J, Kovaleva M, Ferguson L, Barelle C, Porter AJR, Barelle CJ. Ubah OC, et al. Front Immunol. 2017 Dec 22;8:1780. doi: 10.3389/fimmu.2017.01780. eCollection 2017. Front Immunol. 2017. PMID: 29312310 Free PMC article.

8

Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability.

Ubah OC, Buschhaus MJ, Ferguson L, Kovaleva M, Steven J, Porter AJ, Barelle CJ. Ubah OC, et al. Biochem Soc Trans. 2018 Dec 17;46(6):1559-1565. doi: 10.1042/BST20180177. Epub 2018 Oct 31. Biochem Soc Trans. 2018. PMID: 30381336 Review.

9

Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand.

Pepple KL, Wilson L, Van Gelder RN, Kovaleva M, Ubah OC, Steven J, Barelle CJ, Porter A. Pepple KL, et al. Among authors: ubah oc. Transl Vis Sci Technol. 2019 Sep 18;8(5):11. doi: 10.1167/tvst.8.5.11. eCollection 2019 Sep. Transl Vis Sci Technol. 2019. PMID: 31588375 Free PMC article.

10

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development.

Steven J, Müller MR, Carvalho MF, Ubah OC, Kovaleva M, Donohoe G, Baddeley T, Cornock D, Saunders K, Porter AJ, Barelle CJ. Steven J, et al. Among authors: ubah oc. Front Immunol. 2017 Oct 23;8:1361. doi: 10.3389/fimmu.2017.01361. eCollection 2017. Front Immunol. 2017. PMID: 29109729 Free PMC article.

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