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Page 1
Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.
Liu Y, Li Q, Alikarami F, Barrett DR, Mahdavi L, Li H, Tang S, Khan TA, Michino M, Hill C, Song L, Yang L, Li Y, Pokharel SP, Stamford AW, Liverton N, Renzetti LM, Taylor S, Watt GF, Ladduwahetty T, Kargman S, Meinke PT, Foley MA, Shi J, Li H, Carroll M, Chen CW, Gardini A, Maillard I, Huggins DJ, Bernt KM, Wan L. Liu Y, et al. Among authors: bernt km. Cancer Discov. 2022 Nov 2;12(11):2684-2709. doi: 10.1158/2159-8290.CD-21-1307. Cancer Discov. 2022. PMID: 36053276 Free PMC article.
Menin is necessary for long term maintenance of meningioma-1 driven leukemia.
Libbrecht C, Xie HM, Kingsley MC, Haladyna JN, Riedel SS, Alikarami F, Lenard A, McGeehan GM, Ernst P, Bernt KM. Libbrecht C, et al. Among authors: bernt km. Leukemia. 2021 May;35(5):1405-1417. doi: 10.1038/s41375-021-01146-z. Epub 2021 Feb 4. Leukemia. 2021. PMID: 33542482 Free PMC article.
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.
Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. Cao Z, et al. Among authors: bernt km. Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. Mol Cell. 2021. PMID: 34358447 Free PMC article.
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K. Chen C, et al. Among authors: bernt km. Blood. 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442. Blood. 2022. PMID: 34864916 Free PMC article.
FLT3 tyrosine kinase inhibition modulates PRC2 and promotes differentiation in acute myeloid leukemia.
Sung PJ, Selvam M, Riedel SS, Xie HM, Bryant K, Manning B, Wertheim GB, Kulej K, Pham L, Bowman RL, Peresie J, Nemeth MJ, Levine RL, Garcia BA, Meyer SE, Sidoli S, Bernt KM, Carroll M. Sung PJ, et al. Among authors: bernt km. Leukemia. 2024 Feb;38(2):291-301. doi: 10.1038/s41375-023-02131-4. Epub 2024 Jan 5. Leukemia. 2024. PMID: 38182819 Free PMC article.
AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.
Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA. Deshpande AJ, et al. Among authors: bernt km. Cancer Cell. 2014 Dec 8;26(6):896-908. doi: 10.1016/j.ccell.2014.10.009. Epub 2014 Nov 20. Cancer Cell. 2014. PMID: 25464900 Free PMC article.
Identification and Characterization of Chemotherapy-Resistant High-Risk Neuroblastoma Persister Cells.
Grossmann LD, Chen CH, Uzun Y, Thadi A, Wolpaw AJ, Louault K, Goldstein Y, Surrey LF, Martinez D, Calafatti M, Gerelus M, Gao P, Lee L, Patel K, Kaufman RS, Shani G, Farrel A, Moshitch-Moshkovitz S, Grimaldi P, Shapiro M, Kendsersky NM, Lindsay JM, Casey CE, Krytska K, Scolaro L, Tsang M, Groff D, Matkar S, Kalna JR, Mycek E, McDevitt J, Runbeck E, Patel T, Bernt KM, Asgharzadeh S, DeClerck YA, Mossé YP, Tan K, Maris JM. Grossmann LD, et al. Among authors: bernt km. Cancer Discov. 2024 Dec 2;14(12):2387-2406. doi: 10.1158/2159-8290.CD-24-0046. Cancer Discov. 2024. PMID: 39083807 Free PMC article.
CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma.
Pascual-Pasto G, McIntyre B, Hines MG, Giudice AM, Garcia-Gerique L, Hoffmann J, Mishra P, Matlaga S, Lombardi S, Shraim R, Schürch PM, Yarmarkovich M, Hofmann TJ, Alikarami F, Martinez D, Tsang M, Gil-de-Gómez L, Spear TT, Bernt KM, Wolpaw AJ, Dimitrov DS, Li W, Bosse KR. Pascual-Pasto G, et al. Among authors: bernt km. Nat Commun. 2024 Aug 21;15(1):7141. doi: 10.1038/s41467-024-51337-2. Nat Commun. 2024. PMID: 39164224 Free PMC article.
64 results