Hirasawa M - Search Results

1

Potent and Selective PTDSS1 Inhibitors Induce Collateral Lethality in Cancers with PTDSS2 Deletion.

Yoshihama Y, Namiki H, Kato T, Shimazaki N, Takaishi S, Kadoshima-Yamaoka K, Yukinaga H, Maeda N, Shibutani T, Fujimoto K, Hirasawa M, Goto H, Wada N, Tsutsumi S, Hirota Y, Ishikawa T, Yamamoto S. Yoshihama Y, et al. Among authors: hirasawa m. Cancer Res. 2022 Nov 2;82(21):4031-4043. doi: 10.1158/0008-5472.CAN-22-1006. Cancer Res. 2022. PMID: 36054550

2

Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor.

Honma D, Kanno O, Watanabe J, Kinoshita J, Hirasawa M, Nosaka E, Shiroishi M, Takizawa T, Yasumatsu I, Horiuchi T, Nakao A, Suzuki K, Yamasaki T, Nakajima K, Hayakawa M, Yamazaki T, Yadav AS, Adachi N. Honma D, et al. Among authors: hirasawa m. Cancer Sci. 2017 Oct;108(10):2069-2078. doi: 10.1111/cas.13326. Epub 2017 Aug 8. Cancer Sci. 2017. PMID: 28741798 Free PMC article.

3

Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.

Grandjean JM, Jiu AY, West JW, Aoyagi A, Droege DG, Elepano M, Hirasawa M, Hirouchi M, Murakami R, Lee J, Sasaki K, Hirano S, Ohyama T, Tang BC, Vaz RJ, Inoue M, Olson SH, Prusiner SB, Conrad J, Paras NA. Grandjean JM, et al. Among authors: hirasawa m. ACS Med Chem Lett. 2020 Jan 30;11(2):127-132. doi: 10.1021/acsmedchemlett.9b00480. eCollection 2020 Feb 13. ACS Med Chem Lett. 2020. PMID: 32071678 Free PMC article.

4

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.

Yenerall P, Das AK, Wang S, Kollipara RK, Li LS, Villalobos P, Flaming J, Lin YF, Huffman K, Timmons BC, Gilbreath C, Sonavane R, Kinch LN, Rodriguez-Canales J, Moran C, Behrens C, Hirasawa M, Takata T, Murakami R, Iwanaga K, Chen BPC, Grishin NV, Raj GV, Wistuba II, Minna JD, Kittler R. Yenerall P, et al. Among authors: hirasawa m. Cell Chem Biol. 2020 Jan 16;27(1):105-121.e14. doi: 10.1016/j.chembiol.2019.12.005. Epub 2019 Dec 26. Cell Chem Biol. 2020. PMID: 31883965 Free PMC article.

5

Detection of Abacavir-Induced Structural Alterations in Human Leukocyte Antigen-B*57 : 01 Using Phage Display.

Shirayanagi T, Aoki S, Fujimori S, Watanabe K, Aida T, Hirasawa M, Kumagai K, Hoshino T, Ito K. Shirayanagi T, et al. Among authors: hirasawa m. Biol Pharm Bull. 2020;43(6):1007-1015. doi: 10.1248/bpb.b20-00102. Biol Pharm Bull. 2020. PMID: 32475910 Free article.

6

The Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB1*07:01.

Hirasawa M, Hagihara K, Okudaira N, Izumi T. Hirasawa M, et al. PLoS One. 2015 Jun 22;10(6):e0130928. doi: 10.1371/journal.pone.0130928. eCollection 2015. PLoS One. 2015. PMID: 26098642 Free PMC article.

7

Interaction of Nevirapine with the Peptide Binding Groove of HLA-DRB1*01:01 and Its Effect on the Conformation of HLA-Peptide Complex.

Hirasawa M, Hagihara K, Abe K, Ando O, Hirayama N. Hirasawa M, et al. Int J Mol Sci. 2018 Jun 4;19(6):1660. doi: 10.3390/ijms19061660. Int J Mol Sci. 2018. PMID: 29867033 Free PMC article.

8

In Silico and In Vitro Analysis of Interaction between Ximelagatran and Human Leukocyte Antigen (HLA)-DRB1*07:01.

Hirasawa M, Hagihara K, Abe K, Ando O, Hirayama N. Hirasawa M, et al. Int J Mol Sci. 2017 Mar 24;18(4):694. doi: 10.3390/ijms18040694. Int J Mol Sci. 2017. PMID: 28338626 Free PMC article.

9

Synthesis and evaluation of (-)- and (+)-[¹¹C]galanthamine as PET tracers for cerebral acetylcholinesterase imaging.

Kimura H, Kawai T, Hamashima Y, Kawashima H, Miura K, Nakaya Y, Hirasawa M, Arimitsu K, Kajimoto T, Ohmomo Y, Ono M, Node M, Saji H. Kimura H, et al. Among authors: hirasawa m. Bioorg Med Chem. 2014 Jan 1;22(1):285-91. doi: 10.1016/j.bmc.2013.11.026. Epub 2013 Nov 22. Bioorg Med Chem. 2014. PMID: 24315193 Free article.

10

The Extension of the LeiCNS-PK3.0 Model in Combination with the "Handshake" Approach to Understand Brain Tumor Pathophysiology.

Hirasawa M, Saleh MAA, de Lange ECM. Hirasawa M, et al. Pharm Res. 2022 Jul;39(7):1343-1361. doi: 10.1007/s11095-021-03154-1. Epub 2022 Mar 7. Pharm Res. 2022. PMID: 35258766 Free PMC article.

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