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Chemoproteomics-Enabled Identification of 4-Oxo-β-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.
Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, Podlesainski D, Vieira AC, Kiefersauer R, Félix R, Rodrigues T, Lucas SD, Groß O, Geiss-Friedlander R, Cravatt BF, Huber R, Kaiser M, Moreira R. Carvalho LAR, et al. Among authors: huber r. Angew Chem Int Ed Engl. 2022 Nov 21;61(47):e202210498. doi: 10.1002/anie.202210498. Epub 2022 Oct 28. Angew Chem Int Ed Engl. 2022. PMID: 36089535 Free PMC article.
Aerosol-based ligand soaking of reservoir-free protein crystals.
Ross B, Krapp S, Geiss-Friedlander R, Littmann W, Huber R, Kiefersauer R. Ross B, et al. Among authors: huber r. J Appl Crystallogr. 2021 May 28;54(Pt 3):895-902. doi: 10.1107/S1600576721003551. eCollection 2021 Jun 1. J Appl Crystallogr. 2021. PMID: 34188616 Free PMC article.
Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair.
Bolgi O, Silva-Garcia M, Ross B, Pilla E, Kari V, Killisch M, Spitzner M, Stark N, Lenz C, Weiss K, Donzelli L, Gorrell MD, Grade M, Riemer J, Urlaub H, Dobbelstein M, Huber R, Geiss-Friedlander R. Bolgi O, et al. Among authors: huber r. EMBO Rep. 2022 Oct 6;23(10):e54136. doi: 10.15252/embr.202154136. Epub 2022 Aug 1. EMBO Rep. 2022. PMID: 35912982 Free PMC article.
IR laser-induced protein crystal transformation.
Kiefersauer R, Grandl B, Krapp S, Huber R. Kiefersauer R, et al. Among authors: huber r. Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1224-32. doi: 10.1107/S1399004714002223. Epub 2014 Apr 26. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24816092 Free PMC article.
Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution.
Dobbek H, Gremer L, Kiefersauer R, Huber R, Meyer O. Dobbek H, et al. Among authors: huber r. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15971-6. doi: 10.1073/pnas.212640899. Proc Natl Acad Sci U S A. 2002. PMID: 12475995 Free PMC article.
The previously reported active-site structure [Dobbek, H., Gremer, L., Meyer, O. & Huber, R. (1999) Proc. Natl. Acad. Sci. USA 96, 8884-8889] of an Mo with three oxygen ligands and an SeH-group bound to the Sgamma atom of Cys-388 could not be confirmed. ...
The previously reported active-site structure [Dobbek, H., Gremer, L., Meyer, O. & Huber, R. (1999) Proc. Natl. Acad. Sci. …
2,430 results