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Page 1
Structure function analysis of ADP-dependent cyanobacterial phosphofructokinase reveals new phylogenetic grouping in the PFK-A family.
Shen L, Peraglie C, Podlesainski D, Stracke C, Ojha RS, Caliebe F, Kaiser M, Forchhammer K, Hagemann M, Gutekunst K, Snoep JL, Bräsen C, Siebers B. Shen L, et al. Among authors: podlesainski d. J Biol Chem. 2024 Nov;300(11):107868. doi: 10.1016/j.jbc.2024.107868. Epub 2024 Oct 10. J Biol Chem. 2024. PMID: 39393572 Free PMC article.
Rational correction of pathogenic conformational defects in HTRA1.
Beaufort N, Ingendahl L, Merdanovic M, Schmidt A, Podlesainski D, Richter T, Neumann T, Kuszner M, Vetter IR, Stege P, Burston SG, Filipovic A, Ruiz-Blanco YB, Bravo-Rodriguez K, Mieres-Perez J, Beuck C, Uebel S, Zobawa M, Schillinger J, Malik R, Todorov-Völgyi K, Rey J, Roberti A, Hagemeier B, Wefers B, Müller SA, Wurst W, Sanchez-Garcia E, Zimmermann A, Hu XY, Clausen T, Huber R, Lichtenthaler SF, Schmuck C, Giese M, Kaiser M, Ehrmann M, Dichgans M. Beaufort N, et al. Among authors: podlesainski d. Nat Commun. 2024 Jul 16;15(1):5944. doi: 10.1038/s41467-024-49982-8. Nat Commun. 2024. PMID: 39013852 Free PMC article.
The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113.
Podlesainski D, Adeniyi ET, Gröner Y, Schulz F, Krisilia V, Rehberg N, Richter T, Sehr D, Xie H, Simons VE, Kiffe-Delf AL, Kaschani F, Ioerger TR, Kaiser M, Kalscheuer R. Podlesainski D, et al. Cell Chem Biol. 2024 Oct 17;31(10):1755-1771.e73. doi: 10.1016/j.chembiol.2024.06.002. Epub 2024 Jul 8. Cell Chem Biol. 2024. PMID: 38981479 Free article.
Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
Hoi DM, Junker S, Junk L, Schwechel K, Fischel K, Podlesainski D, Hawkins PME, van Geelen L, Kaschani F, Leodolter J, Morreale FE, Kleine S, Guha S, Rumpel K, Schmiedel VM, Weinstabl H, Meinhart A, Payne RJ, Kaiser M, Hartl M, Boehmelt G, Kazmaier U, Kalscheuer R, Clausen T. Hoi DM, et al. Among authors: podlesainski d. Cell. 2023 May 11;186(10):2176-2192.e22. doi: 10.1016/j.cell.2023.04.009. Epub 2023 May 2. Cell. 2023. PMID: 37137307 Free article.
Chemoproteomics-Enabled Identification of 4-Oxo-β-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.
Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, Podlesainski D, Vieira AC, Kiefersauer R, Félix R, Rodrigues T, Lucas SD, Groß O, Geiss-Friedlander R, Cravatt BF, Huber R, Kaiser M, Moreira R. Carvalho LAR, et al. Among authors: podlesainski d. Angew Chem Int Ed Engl. 2022 Nov 21;61(47):e202210498. doi: 10.1002/anie.202210498. Epub 2022 Oct 28. Angew Chem Int Ed Engl. 2022. PMID: 36089535 Free PMC article.
BacPROTACs mediate targeted protein degradation in bacteria.
Morreale FE, Kleine S, Leodolter J, Junker S, Hoi DM, Ovchinnikov S, Okun A, Kley J, Kurzbauer R, Junk L, Guha S, Podlesainski D, Kazmaier U, Boehmelt G, Weinstabl H, Rumpel K, Schmiedel VM, Hartl M, Haselbach D, Meinhart A, Kaiser M, Clausen T. Morreale FE, et al. Among authors: podlesainski d. Cell. 2022 Jun 23;185(13):2338-2353.e18. doi: 10.1016/j.cell.2022.05.009. Epub 2022 Jun 3. Cell. 2022. PMID: 35662409 Free PMC article.