Kümmel D - Search Results

1

Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.

Shvarev D, Schoppe J, König C, Perz A, Füllbrunn N, Kiontke S, Langemeyer L, Januliene D, Schnelle K, Kümmel D, Fröhlich F, Moeller A, Ungermann C. Shvarev D, et al. Among authors: kummel d. Elife. 2022 Sep 13;11:e80901. doi: 10.7554/eLife.80901. Elife. 2022. PMID: 36098503 Free PMC article.

2

Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins.

Pasch T, Schröder A, Kattelmann S, Eisenstein M, Pietrokovski S, Kümmel D, Mootz HD. Pasch T, et al. Among authors: kummel d. Chem Sci. 2023 Apr 24;14(19):5204-5213. doi: 10.1039/d3sc01200j. eCollection 2023 May 17. Chem Sci. 2023. PMID: 37206380 Free PMC article.

3

Principles of membrane tethering and fusion in endosome and lysosome biogenesis.

Kümmel D, Ungermann C. Kümmel D, et al. Curr Opin Cell Biol. 2014 Aug;29:61-6. doi: 10.1016/j.ceb.2014.04.007. Epub 2014 May 17. Curr Opin Cell Biol. 2014. PMID: 24813801 Review.

4

Structural identification of the Vps18 β-propeller reveals a critical role in the HOPS complex stability and function.

Behrmann H, Lürick A, Kuhlee A, Balderhaar HK, Bröcker C, Kümmel D, Engelbrecht-Vandré S, Gohlke U, Raunser S, Heinemann U, Ungermann C. Behrmann H, et al. Among authors: kummel d. J Biol Chem. 2014 Nov 28;289(48):33503-12. doi: 10.1074/jbc.M114.602714. Epub 2014 Oct 16. J Biol Chem. 2014. PMID: 25324549 Free PMC article.

5

The Habc domain of the SNARE Vam3 interacts with the HOPS tethering complex to facilitate vacuole fusion.

Lürick A, Kuhlee A, Bröcker C, Kümmel D, Raunser S, Ungermann C. Lürick A, et al. Among authors: kummel d. J Biol Chem. 2015 Feb 27;290(9):5405-13. doi: 10.1074/jbc.M114.631465. Epub 2015 Jan 6. J Biol Chem. 2015. PMID: 25564619 Free PMC article.

6

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.

Zech R, Kiontke S, Mueller U, Oeckinghaus A, Kümmel D. Zech R, et al. Among authors: kummel d. J Biol Chem. 2016 Sep 16;291(38):20008-20. doi: 10.1074/jbc.M116.732446. Epub 2016 Aug 4. J Biol Chem. 2016. PMID: 27493206 Free PMC article.

7

Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1.

Kiontke S, Langemeyer L, Kuhlee A, Schuback S, Raunser S, Ungermann C, Kümmel D. Kiontke S, et al. Among authors: kummel d. Nat Commun. 2017 Jan 4;8:14034. doi: 10.1038/ncomms14034. Nat Commun. 2017. PMID: 28051187 Free PMC article.

8

A guanine nucleotide exchange factor (GEF) limits Rab GTPase-driven membrane fusion.

Langemeyer L, Perz A, Kümmel D, Ungermann C. Langemeyer L, et al. Among authors: kummel d. J Biol Chem. 2018 Jan 12;293(2):731-739. doi: 10.1074/jbc.M117.812941. Epub 2017 Nov 28. J Biol Chem. 2018. PMID: 29184002 Free PMC article.

9

Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure.

Gao J, Langemeyer L, Kümmel D, Reggiori F, Ungermann C. Gao J, et al. Among authors: kummel d. Elife. 2018 Feb 15;7:e31145. doi: 10.7554/eLife.31145. Elife. 2018. PMID: 29446751 Free PMC article.

10

Multisubunit tethers in membrane fusion.

Lürick A, Kümmel D, Ungermann C. Lürick A, et al. Among authors: kummel d. Curr Biol. 2018 Apr 23;28(8):R417-R420. doi: 10.1016/j.cub.2017.12.012. Curr Biol. 2018. PMID: 29689226 Free article. Review.

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