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Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins.
Gao J, Mewborne QT, Girdhar A, Sheth U, Coyne AN, Punathil R, Kang BG, Dasovich M, Veire A, DeJesus Hernandez M, Liu S, Shi Z, Dafinca R, Fouquerel E, Talbot K, Kam TI, Zhang YJ, Dickson D, Petrucelli L, van Blitterswijk M, Guo L, Dawson TM, Dawson VL, Leung AKL, Lloyd TE, Gendron TF, Rothstein JD, Zhang K. Gao J, et al. Among authors: sheth u. Sci Transl Med. 2022 Sep 14;14(662):eabq3215. doi: 10.1126/scitranslmed.abq3215. Epub 2022 Sep 14. Sci Transl Med. 2022. PMID: 36103513 Free PMC article.
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo.
Riemenschneider H, Simonetti F, Sheth U, Katona E, Roth S, Hutten S, Farny D, Michaelsen M, Nuscher B, Schmidt MK, Flatley A, Schepers A, Gruijs da Silva LA, Zhou Q, Klopstock T, Liesz A, Arzberger T, Herms J, Feederle R, Gendron TF, Dormann D, Edbauer D. Riemenschneider H, et al. Among authors: sheth u. Acta Neuropathol Commun. 2023 Jul 11;11(1):112. doi: 10.1186/s40478-023-01592-z. Acta Neuropathol Commun. 2023. PMID: 37434215 Free PMC article.
Aberrant splicing exonizes C9ORF72 repeat expansion in ALS/FTD.
Yang S, Wijegunawardana D, Sheth U, Veire AM, Salgado JMS, Agrawal M, Zhou J, Pereira JD, Gendron TF, Guo JU. Yang S, et al. Among authors: sheth u. bioRxiv [Preprint]. 2023 Nov 14:2023.11.13.566896. doi: 10.1101/2023.11.13.566896. bioRxiv. 2023. PMID: 38014069 Free PMC article. Preprint.
Fluid biomarkers for amyotrophic lateral sclerosis: a review.
Irwin KE, Sheth U, Wong PC, Gendron TF. Irwin KE, et al. Among authors: sheth u. Mol Neurodegener. 2024 Jan 24;19(1):9. doi: 10.1186/s13024-023-00685-6. Mol Neurodegener. 2024. PMID: 38267984 Free PMC article. Review.
311 results