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Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids.
Llewellyn SV, Kermanizadeh A, Ude V, Jacobsen NR, Conway GE, Shah UK, Niemeijer M, Moné MJ, van de Water B, Roy S, Moritz W, Stone V, Jenkins GJS, Doak SH. Llewellyn SV, et al. Among authors: van de water b. Toxicol In Vitro. 2022 Dec;85:105473. doi: 10.1016/j.tiv.2022.105473. Epub 2022 Sep 13. Toxicol In Vitro. 2022. PMID: 36108805 Free article.
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.
Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG. Albrecht W, et al. Among authors: van aerts l, van thriel c, van de water b. Arch Toxicol. 2019 Jun;93(6):1609-1637. doi: 10.1007/s00204-019-02492-9. Epub 2019 Jun 27. Arch Toxicol. 2019. PMID: 31250071
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods.
Krebs A, van Vugt-Lussenburg BMA, Waldmann T, Albrecht W, Boei J, Ter Braak B, Brajnik M, Braunbeck T, Brecklinghaus T, Busquet F, Dinnyes A, Dokler J, Dolde X, Exner TE, Fisher C, Fluri D, Forsby A, Hengstler JG, Holzer AK, Janstova Z, Jennings P, Kisitu J, Kobolak J, Kumar M, Limonciel A, Lundqvist J, Mihalik B, Moritz W, Pallocca G, Ulloa APC, Pastor M, Rovida C, Sarkans U, Schimming JP, Schmidt BZ, Stöber R, Strassfeld T, van de Water B, Wilmes A, van der Burg B, Verfaillie CM, von Hellfeld R, Vrieling H, Vrijenhoek NG, Leist M. Krebs A, et al. Among authors: van de water b, van vugt lussenburg bma, van der burg b. Arch Toxicol. 2020 Jul;94(7):2435-2461. doi: 10.1007/s00204-020-02802-6. Epub 2020 Jul 6. Arch Toxicol. 2020. PMID: 32632539 Free PMC article.
Utility of Extrapolating Human S1500+ Genes to the Whole Transcriptome: Tunicamycin Case Study.
Mav D, Phadke DP, Balik-Meisner MR, Merrick BA, Auerbach S, Niemeijer M, Huppelschoten S, Baze A, Parmentier C, Richert L, van de Water B, Shah RR, Paules RS. Mav D, et al. Among authors: van de water b. Bioinform Biol Insights. 2020 Sep 29;14:1177932220952742. doi: 10.1177/1177932220952742. eCollection 2020. Bioinform Biol Insights. 2020. PMID: 33088175 Free PMC article.
Comparing in vitro human liver models to in vivo human liver using RNA-Seq.
Gupta R, Schrooders Y, Hauser D, van Herwijnen M, Albrecht W, Ter Braak B, Brecklinghaus T, Castell JV, Elenschneider L, Escher S, Guye P, Hengstler JG, Ghallab A, Hansen T, Leist M, Maclennan R, Moritz W, Tolosa L, Tricot T, Verfaillie C, Walker P, van de Water B, Kleinjans J, Caiment F. Gupta R, et al. Among authors: van herwijnen m, van de water b. Arch Toxicol. 2021 Feb;95(2):573-589. doi: 10.1007/s00204-020-02937-6. Epub 2020 Oct 27. Arch Toxicol. 2021. PMID: 33106934 Free PMC article.
262 results