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PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice.
Wu CY, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ, Crawford HC. Wu CY, et al. Among authors: carpenter es. Gastroenterology. 2014 Dec;147(6):1405-16.e7. doi: 10.1053/j.gastro.2014.08.032. Epub 2014 Aug 27. Gastroenterology. 2014. PMID: 25311989 Free PMC article.
Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis.
Zhang Y, Lazarus J, Steele NG, Yan W, Lee HJ, Nwosu ZC, Halbrook CJ, Menjivar RE, Kemp SB, Sirihorachai VR, Velez-Delgado A, Donahue K, Carpenter ES, Brown KL, Irizarry-Negron V, Nevison AC, Vinta A, Anderson MA, Crawford HC, Lyssiotis CA, Frankel TL, Bednar F, Pasca di Magliano M. Zhang Y, et al. Among authors: carpenter es. Cancer Discov. 2020 Mar;10(3):422-439. doi: 10.1158/2159-8290.CD-19-0958. Epub 2020 Jan 7. Cancer Discov. 2020. PMID: 31911451 Free PMC article.
Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer.
Steele NG, Biffi G, Kemp SB, Zhang Y, Drouillard D, Syu L, Hao Y, Oni TE, Brosnan E, Elyada E, Doshi A, Hansma C, Espinoza C, Abbas A, The S, Irizarry-Negron V, Halbrook CJ, Franks NE, Hoffman MT, Brown K, Carpenter ES, Nwosu ZC, Johnson C, Lima F, Anderson MA, Park Y, Crawford HC, Lyssiotis CA, Frankel TL, Rao A, Bednar F, Dlugosz AA, Preall JB, Tuveson DA, Allen BL, Pasca di Magliano M. Steele NG, et al. Among authors: carpenter es. Clin Cancer Res. 2021 Apr 1;27(7):2023-2037. doi: 10.1158/1078-0432.CCR-20-3715. Epub 2021 Jan 25. Clin Cancer Res. 2021. PMID: 33495315 Free PMC article.
Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages.
Kemp SB, Steele NG, Carpenter ES, Donahue KL, Bushnell GG, Morris AH, The S, Orbach SM, Sirihorachai VR, Nwosu ZC, Espinoza C, Lima F, Brown K, Girgis AA, Gunchick V, Zhang Y, Lyssiotis CA, Frankel TL, Bednar F, Rao A, Sahai V, Shea LD, Crawford HC, Pasca di Magliano M. Kemp SB, et al. Among authors: carpenter es. Life Sci Alliance. 2021 Mar 29;4(6):e202000935. doi: 10.26508/lsa.202000935. Print 2021 Jun. Life Sci Alliance. 2021. PMID: 33782087 Free PMC article.
Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1.
Kemp SB, Carpenter ES, Steele NG, Donahue KL, Nwosu ZC, Pacheco A, Velez-Delgado A, Menjivar RE, Lima F, The S, Espinoza CE, Brown K, Long D, Lyssiotis CA, Rao A, Zhang Y, Pasca di Magliano M, Crawford HC. Kemp SB, et al. Among authors: carpenter es. Cancer Res. 2021 Aug 15;81(16):4305-4318. doi: 10.1158/0008-5472.CAN-20-3929. Epub 2021 May 28. Cancer Res. 2021. PMID: 34049975 Free PMC article.
Multimodal Mapping of the Tumor and Peripheral Blood Immune Landscape in Human Pancreatic Cancer.
Steele NG, Carpenter ES, Kemp SB, Sirihorachai VR, The S, Delrosario L, Lazarus J, Amir ED, Gunchick V, Espinoza C, Bell S, Harris L, Lima F, Irizarry-Negron V, Paglia D, Macchia J, Chu AKY, Schofield H, Wamsteker EJ, Kwon R, Schulman A, Prabhu A, Law R, Sondhi A, Yu J, Patel A, Donahue K, Nathan H, Cho C, Anderson MA, Sahai V, Lyssiotis CA, Zou W, Allen BL, Rao A, Crawford HC, Bednar F, Frankel TL, Pasca di Magliano M. Steele NG, et al. Among authors: carpenter es. Nat Cancer. 2020 Nov;1(11):1097-1112. doi: 10.1038/s43018-020-00121-4. Epub 2020 Oct 26. Nat Cancer. 2020. PMID: 34296197 Free PMC article.
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis.
Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, Mbah NE, Shan M, Das NK, Magnuson B, Little AC, Savani MR, Ramos J, Gao T, Sastra SA, Palermo CF, Badgley MA, Zhang L, Asara JM, McBrayer SK, di Magliano MP, Crawford HC, Shah YM, Olive KP, Lyssiotis CA. Kremer DM, et al. Among authors: carpenter es. Nat Commun. 2021 Aug 11;12(1):4860. doi: 10.1038/s41467-021-24859-2. Nat Commun. 2021. PMID: 34381026 Free PMC article.
49 results