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Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling.
Mishra S, Cosentino C, Tamta AK, Khan D, Srinivasan S, Ravi V, Abbotto E, Arathi BP, Kumar S, Jain A, Ramaian AS, Kizkekra SM, Rajagopal R, Rao S, Krishna S, Asirvatham-Jeyaraj N, Haggerty ER, Silberman DM, Kurland IJ, Veeranna RP, Jayavelu T, Bruzzone S, Mostoslavsky R, Sundaresan NR. Mishra S, et al. Among authors: cosentino c. Nat Commun. 2022 Sep 15;13(1):5415. doi: 10.1038/s41467-022-32905-w. Nat Commun. 2022. PMID: 36109503 Free PMC article.
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. Sebastián C, et al. Among authors: cosentino c. Cell. 2012 Dec 7;151(6):1185-99. doi: 10.1016/j.cell.2012.10.047. Cell. 2012. PMID: 23217706 Free PMC article.
Metabolism, longevity and epigenetics.
Cosentino C, Mostoslavsky R. Cosentino C, et al. Cell Mol Life Sci. 2013 May;70(9):1525-41. doi: 10.1007/s00018-013-1295-3. Epub 2013 Mar 7. Cell Mol Life Sci. 2013. PMID: 23467663 Free PMC article. Review.
SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.
Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D'Urso A, Näär AM, Kingston R, Rippe K, Mostoslavsky R. Toiber D, et al. Among authors: cosentino c. Mol Cell. 2013 Aug 22;51(4):454-68. doi: 10.1016/j.molcel.2013.06.018. Epub 2013 Aug 1. Mol Cell. 2013. PMID: 23911928 Free PMC article.
SIRT6 is a key regulator of mitochondrial function in the brain.
Smirnov D, Eremenko E, Stein D, Kaluski S, Jasinska W, Cosentino C, Martinez-Pastor B, Brotman Y, Mostoslavsky R, Khrameeva E, Toiber D. Smirnov D, et al. Among authors: cosentino c. Cell Death Dis. 2023 Jan 18;14(1):35. doi: 10.1038/s41419-022-05542-w. Cell Death Dis. 2023. PMID: 36653345 Free PMC article.
High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX.
Singh I, Ozturk N, Cordero J, Mehta A, Hasan D, Cosentino C, Sebastian C, Krüger M, Looso M, Carraro G, Bellusci S, Seeger W, Braun T, Mostoslavsky R, Barreto G. Singh I, et al. Among authors: cosentino c. Cell Res. 2015 Jul;25(7):837-50. doi: 10.1038/cr.2015.67. Epub 2015 Jun 5. Cell Res. 2015. PMID: 26045162 Free PMC article.
Assessing kinetics and recruitment of DNA repair factors using high content screens.
Martinez-Pastor B, Silveira GG, Clarke TL, Chung D, Gu Y, Cosentino C, Davidow LS, Mata G, Hassanieh S, Salsman J, Ciccia A, Bae N, Bedford MT, Megias D, Rubin LL, Efeyan A, Dellaire G, Mostoslavsky R. Martinez-Pastor B, et al. Among authors: cosentino c. Cell Rep. 2021 Dec 28;37(13):110176. doi: 10.1016/j.celrep.2021.110176. Cell Rep. 2021. PMID: 34965416 Free PMC article.
306 results