Chen X - Search Results

1

Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions.

Zhang P, Brinton LT, Gharghabi M, Sher S, Williams K, Cannon M, Walker JS, Canfield D, Beaver L, Cempre CB, Phillips H, Chen X, Yan P, Lehman A, Scherle P, Wang M, Vaddi K, Baiocchi R, Wang R, Sampath D, Alinari L, Blachly JS, Lapalombella R. Zhang P, et al. Among authors: chen x. Sci Adv. 2022 Sep 16;8(37):eabp9005. doi: 10.1126/sciadv.abp9005. Epub 2022 Sep 16. Sci Adv. 2022. PMID: 36112677 Free PMC article.

2

MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent.

Wang T, Liu L, Chen X, Shen Y, Lian G, Shah N, Davidoff AM, Yang J, Wang R. Wang T, et al. Among authors: chen x. Cell Death Dis. 2018 Feb 14;9(2):220. doi: 10.1038/s41419-018-0295-5. Cell Death Dis. 2018. PMID: 29445162 Free PMC article.

3

Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G₂/M-phase transition.

Shen Y, Sherman JW, Chen X, Wang R. Shen Y, et al. Among authors: chen x. J Biol Chem. 2018 Apr 6;293(14):5185-5199. doi: 10.1074/jbc.RA117.001379. Epub 2018 Feb 21. J Biol Chem. 2018. PMID: 29467227 Free PMC article.

4

Radioisotope-Based Protocol for Determination of Central Carbon Metabolism in T Cells.

Chen X, Sherman JW, Wang R. Chen X, et al. Methods Mol Biol. 2020;2111:257-265. doi: 10.1007/978-1-0716-0266-9_20. Methods Mol Biol. 2020. PMID: 31933213

5

De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function.

Wu R, Chen X, Kang S, Wang T, Gnanaprakasam JR, Yao Y, Liu L, Fan G, Burns MR, Wang R. Wu R, et al. Among authors: chen x. Sci Adv. 2020 Dec 16;6(51):eabc4275. doi: 10.1126/sciadv.abc4275. Print 2020 Dec. Sci Adv. 2020. PMID: 33328226 Free PMC article.

6

The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation.

Chen X, Liu L, Kang S, Gnanaprakasam JR, Wang R. Chen X, et al. Sci Adv. 2023 Mar 24;9(12):eadd9554. doi: 10.1126/sciadv.add9554. Epub 2023 Mar 24. Sci Adv. 2023. PMID: 36961904 Free PMC article.

7

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.

Lian G, Gnanaprakasam JR, Wang T, Wu R, Chen X, Liu L, Shen Y, Yang M, Yang J, Chen Y, Vasiliou V, Cassel TA, Green DR, Liu Y, Fan TW, Wang R. Lian G, et al. Among authors: chen x, chen y. Elife. 2018 Sep 10;7:e36158. doi: 10.7554/eLife.36158. Elife. 2018. PMID: 30198844 Free PMC article.

8

Inosine is an alternative carbon source for CD8⁺-T-cell function under glucose restriction.

Wang T, Gnanaprakasam JNR, Chen X, Kang S, Xu X, Sun H, Liu L, Rodgers H, Miller E, Cassel TA, Sun Q, Vicente-Muñoz S, Warmoes MO, Lin P, Piedra-Quintero ZL, Guerau-de-Arellano M, Cassady KA, Zheng SG, Yang J, Lane AN, Song X, Fan TW, Wang R. Wang T, et al. Among authors: chen x. Nat Metab. 2020 Jul;2(7):635-647. doi: 10.1038/s42255-020-0219-4. Epub 2020 Jun 15. Nat Metab. 2020. PMID: 32694789 Free PMC article.

9

NAD⁺ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells.

Wang Y, Wang F, Wang L, Qiu S, Yao Y, Yan C, Xiong X, Chen X, Ji Q, Cao J, Gao G, Li D, Zhang L, Guo Z, Wang R, Wang H, Fan G. Wang Y, et al. Among authors: chen x. Cell Rep. 2021 Aug 10;36(6):109516. doi: 10.1016/j.celrep.2021.109516. Cell Rep. 2021. PMID: 34380043 Free article.

10

Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation.

Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Chen X, et al. Sci Immunol. 2022 Apr 29;7(70):eabm8161. doi: 10.1126/sciimmunol.abm8161. Epub 2022 Apr 29. Sci Immunol. 2022. PMID: 35486677 Free PMC article.

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