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Production and nonclinical evaluation of an autologous iPSC-derived platelet product for the iPLAT1 clinical trial.
Sugimoto N, Nakamura S, Shimizu S, Shigemasa A, Kanda J, Matsuyama N, Tanaka M, Hayashi T, Fuchizaki A, Nogawa M, Watanabe N, Okamoto S, Handa M, Sawaguchi A, Momose D, Koh KR, Tani Y, Takaori-Kondo A, Eto K. Sugimoto N, et al. Among authors: sawaguchi a. Blood Adv. 2022 Dec 13;6(23):6056-6069. doi: 10.1182/bloodadvances.2022008512. Blood Adv. 2022. PMID: 36149941 Free PMC article.
iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study.
Sugimoto N, Kanda J, Nakamura S, Kitano T, Hishizawa M, Kondo T, Shimizu S, Shigemasa A, Hirai H, Arai Y, Minami M, Tada H, Momose D, Koh KR, Nogawa M, Watanabe N, Okamoto S, Handa M, Sawaguchi A, Matsuyama N, Tanaka M, Hayashi T, Fuchizaki A, Tani Y, Takaori-Kondo A, Eto K. Sugimoto N, et al. Among authors: sawaguchi a. Blood. 2022 Dec 1;140(22):2398-2402. doi: 10.1182/blood.2022017296. Blood. 2022. PMID: 36112961 Free article. Clinical Trial. No abstract available.
Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.
Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N, Nishi E, Arai F, Nishimura S, Eto K. Ito Y, et al. Among authors: sawaguchi a. Cell. 2018 Jul 26;174(3):636-648.e18. doi: 10.1016/j.cell.2018.06.011. Epub 2018 Jul 12. Cell. 2018. PMID: 30017246 Free article.
Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets.
Hirata S, Murata T, Suzuki D, Nakamura S, Jono-Ohnishi R, Hirose H, Sawaguchi A, Nishimura S, Sugimoto N, Eto K. Hirata S, et al. Among authors: sawaguchi a. Stem Cells Transl Med. 2017 Mar;6(3):720-730. doi: 10.5966/sctm.2016-0104. Epub 2016 Oct 5. Stem Cells Transl Med. 2017. PMID: 28297575 Free PMC article.
iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity.
Suzuki D, Flahou C, Yoshikawa N, Stirblyte I, Hayashi Y, Sawaguchi A, Akasaka M, Nakamura S, Higashi N, Xu H, Matsumoto T, Fujio K, Manz MG, Hotta A, Takizawa H, Eto K, Sugimoto N. Suzuki D, et al. Among authors: sawaguchi a. Stem Cell Reports. 2020 Jan 14;14(1):49-59. doi: 10.1016/j.stemcr.2019.11.011. Epub 2019 Dec 26. Stem Cell Reports. 2020. PMID: 31883921 Free PMC article.
Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs.
Sone M, Nakamura S, Umeda S, Ginya H, Oshima M, Kanashiro MA, Paul SK, Hashimoto K, Nakamura E, Harada Y, Tsujimura K, Saraya A, Yamaguchi T, Sugimoto N, Sawaguchi A, Iwama A, Eto K, Takayama N. Sone M, et al. Among authors: sawaguchi a. Stem Cell Reports. 2021 Dec 14;16(12):2861-2870. doi: 10.1016/j.stemcr.2021.11.001. Epub 2021 Dec 2. Stem Cell Reports. 2021. PMID: 34861163 Free PMC article.
121 results