Somervaille TCP - Search Results

1

HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block.

Maiques-Diaz A, Nicosia L, Basma NJ, Romero-Camarero I, Camera F, Spencer GJ, Amaral FMR, Simeoni F, Wingelhofer B, Williamson AJK, Pierce A, Whetton AD, Somervaille TCP. Maiques-Diaz A, et al. Among authors: somervaille tcp. Oncogene. 2022 Oct;41(44):4841-4854. doi: 10.1038/s41388-022-02471-y. Epub 2022 Sep 28. Oncogene. 2022. PMID: 36171271 Free PMC article.

2

MANIFEST: Pelabresib in Combination With Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Myelofibrosis.

Mascarenhas J, Kremyanskaya M, Patriarca A, Palandri F, Devos T, Passamonti F, Rampal RK, Mead AJ, Hobbs G, Scandura JM, Talpaz M, Granacher N, Somervaille TCP, Hoffman R, Wondergem MJ, Salama ME, Colak G, Cui J, Kiladjian JJ, Vannucchi AM, Verstovsek S, Curto-García N, Harrison C, Gupta V. Mascarenhas J, et al. Among authors: somervaille tcp. J Clin Oncol. 2023 Nov 10;41(32):4993-5004. doi: 10.1200/JCO.22.01972. Epub 2023 Mar 7. J Clin Oncol. 2023. PMID: 36881782 Free PMC article. Clinical Trial.

3

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.

Somervaille TC, Matheny CJ, Spencer GJ, Iwasaki M, Rinn JL, Witten DM, Chang HY, Shurtleff SA, Downing JR, Cleary ML. Somervaille TC, et al. Cell Stem Cell. 2009 Feb 6;4(2):129-40. doi: 10.1016/j.stem.2008.11.015. Cell Stem Cell. 2009. PMID: 19200802 Free PMC article.

4

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.

Harris WJ, Huang X, Lynch JT, Spencer GJ, Hitchin JR, Li Y, Ciceri F, Blaser JG, Greystoke BF, Jordan AM, Miller CJ, Ogilvie DJ, Somervaille TC. Harris WJ, et al. Cancer Cell. 2012 Apr 17;21(4):473-87. doi: 10.1016/j.ccr.2012.03.014. Epub 2012 Mar 29. Cancer Cell. 2012. PMID: 22464800 Free article.

5

TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells.

Lynch JT, Somerville TD, Spencer GJ, Huang X, Somervaille TC. Lynch JT, et al. Cell Death Dis. 2013 Apr 4;4(4):e573. doi: 10.1038/cddis.2013.107. Cell Death Dis. 2013. PMID: 23559008 Free PMC article.

6

Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.

White DJ, Unwin RD, Bindels E, Pierce A, Teng HY, Muter J, Greystoke B, Somerville TD, Griffiths J, Lovell S, Somervaille TC, Delwel R, Whetton AD, Meyer S. White DJ, et al. PLoS One. 2013 Jun 12;8(6):e66510. doi: 10.1371/journal.pone.0066510. Print 2013. PLoS One. 2013. PMID: 23776681 Free PMC article.

7

The variety of leukemic stem cells in myeloid malignancy.

Wiseman DH, Greystoke BF, Somervaille TC. Wiseman DH, et al. Oncogene. 2014 Jun 12;33(24):3091-8. doi: 10.1038/onc.2013.269. Epub 2013 Jul 8. Oncogene. 2014. PMID: 23831573 Review.

8

Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells.

Huang X, Spencer GJ, Lynch JT, Ciceri F, Somerville TD, Somervaille TC. Huang X, et al. Leukemia. 2014 May;28(5):1081-91. doi: 10.1038/leu.2013.316. Epub 2013 Oct 29. Leukemia. 2014. PMID: 24166297 Free PMC article.

9

A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.

Jude JG, Spencer GJ, Huang X, Somerville TDD, Jones DR, Divecha N, Somervaille TCP. Jude JG, et al. Among authors: somervaille tcp. Oncogene. 2015 Mar 5;34(10):1253-1262. doi: 10.1038/onc.2014.77. Epub 2014 Mar 31. Oncogene. 2015. PMID: 24681948 Free PMC article.

10

Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia.

Somerville TD, Wiseman DH, Spencer GJ, Huang X, Lynch JT, Leong HS, Williams EL, Cheesman E, Somervaille TC. Somerville TD, et al. Cancer Cell. 2015 Sep 14;28(3):329-42. doi: 10.1016/j.ccell.2015.07.017. Cancer Cell. 2015. PMID: 26373280 Free article.

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