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Page 1
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program.
Hashimoto M, Araki K, Cardenas MA, Li P, Jadhav RR, Kissick HT, Hudson WH, McGuire DJ, Obeng RC, Wieland A, Lee J, McManus DT, Ross JL, Im SJ, Lee J, Lin JX, Hu B, West EE, Scharer CD, Freeman GJ, Sharpe AH, Ramalingam SS, Pellerin A, Teichgräber V, Greenleaf WJ, Klein C, Goronzy JJ, Umaña P, Leonard WJ, Smith KA, Ahmed R. Hashimoto M, et al. Among authors: mcmanus dt. Nature. 2022 Oct;610(7930):173-181. doi: 10.1038/s41586-022-05257-0. Epub 2022 Sep 28. Nature. 2022. PMID: 36171288 Free PMC article.
Characteristics and anatomic location of PD-1+TCF1+ stem-like CD8 T cells in chronic viral infection and cancer.
Im SJ, Obeng RC, Nasti TH, McManus D, Kamphorst AO, Gunisetty S, Prokhnevska N, Carlisle JW, Yu K, Sica GL, Cardozo LE, Gonçalves ANA, Kissick HT, Nakaya HI, Ramalingam SS, Ahmed R. Im SJ, et al. Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2221985120. doi: 10.1073/pnas.2221985120. Epub 2023 Oct 2. Proc Natl Acad Sci U S A. 2023. PMID: 37782797 Free PMC article.
Early generation of a precursor CD8 T cell that can adapt to acute or chronic viral infection.
McManus DT, Valanparambil RM, Medina CB, Hu Y, Scharer CD, Sobierajska E, Chang DY, Wieland A, Lee J, Nasti TH, Hashimoto M, Ross JL, Prokhnevska N, Cardenas MA, Gill AL, Clark EC, Abadie K, Kueh HY, Kaye J, Au-Yeung BB, Kissick HT, Ahmed R. McManus DT, et al. Res Sq [Preprint]. 2024 Feb 12:rs.3.rs-3922168. doi: 10.21203/rs.3.rs-3922168/v1. Res Sq. 2024. PMID: 38410458 Free PMC article. Preprint.
Lymph node conduits transport virions for rapid T cell activation.
Reynoso GV, Weisberg AS, Shannon JP, McManus DT, Shores L, Americo JL, Stan RV, Yewdell JW, Hickman HD. Reynoso GV, et al. Among authors: mcmanus dt. Nat Immunol. 2019 May;20(5):602-612. doi: 10.1038/s41590-019-0342-0. Epub 2019 Mar 18. Nat Immunol. 2019. PMID: 30886418 Free PMC article.
CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways.
Wein AN, McMaster SR, Takamura S, Dunbar PR, Cartwright EK, Hayward SL, McManus DT, Shimaoka T, Ueha S, Tsukui T, Masumoto T, Kurachi M, Matsushima K, Kohlmeier JE. Wein AN, et al. Among authors: mcmanus dt. J Exp Med. 2019 Dec 2;216(12):2748-2762. doi: 10.1084/jem.20181308. Epub 2019 Sep 26. J Exp Med. 2019. PMID: 31558615 Free PMC article.
An early precursor CD8 T cell that adapts to acute or chronic viral infection.
McManus DT, Valanparambil RM, Medina CB, Scharer CD, McGuire DJ, Sobierajska E, Hu Y, Chang DY, Wieland A, Lee J, Nasti TH, Hashimoto M, Ross JL, Prokhnevska N, Cardenas MA, Gill AL, Clark EC, Abadie K, Kumar A, Kaye J, Au-Yeung BB, Kueh HY, Kissick HT, Ahmed R. McManus DT, et al. Nature. 2025 Jan 8. doi: 10.1038/s41586-024-08562-y. Online ahead of print. Nature. 2025. PMID: 39778710
Immune microenvironment modulation following neoadjuvant therapy for oesophageal adenocarcinoma: a translational analysis of the DEBIOC clinical trial.
Scanlon E, Lavery A, Albraikat M, Stevenson L, Kennedy C, Byrne R, Walker A, Mullan-Young B, McManus DT, Virdee PS, Elhussein L, Turbitt J, Collinson D, Miedzybrodzka Z, Van Schaeybroeck S, McQuaid S, James JA, Craig SG, Blayney JK, Petty RD, Harkin DP, Kennedy RD, Eatock MM, Middleton MR, Thomas A, Turkington RC. Scanlon E, et al. Among authors: mcmanus dt. ESMO Open. 2024 Nov;9(11):103930. doi: 10.1016/j.esmoop.2024.103930. Epub 2024 Oct 11. ESMO Open. 2024. PMID: 39395265 Free PMC article.
57 results