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Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants.
Li Q, Humphries F, Girardin RC, Wallace A, Ejemel M, Amcheslavsky A, McMahon CT, Schiller ZA, Ma Z, Cruz J, Dupuis AP, Payne AF, Maryam A, Yilmaz NK, McDonough KA, Pierce BG, Schiffer CA, Kruse AC, Klempner MS, Cavacini LA, Fitzgerald KA, Wang Y. Li Q, et al. Among authors: klempner ms. Front Immunol. 2022 Sep 12;13:995412. doi: 10.3389/fimmu.2022.995412. eCollection 2022. Front Immunol. 2022. PMID: 36172366 Free PMC article.
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction.
Ejemel M, Li Q, Hou S, Schiller ZA, Tree JA, Wallace A, Amcheslavsky A, Kurt Yilmaz N, Buttigieg KR, Elmore MJ, Godwin K, Coombes N, Toomey JR, Schneider R, Ramchetty AS, Close BJ, Chen DY, Conway HL, Saeed M, Ganesa C, Carroll MW, Cavacini LA, Klempner MS, Schiffer CA, Wang Y. Ejemel M, et al. Among authors: klempner ms. Nat Commun. 2020 Aug 21;11(1):4198. doi: 10.1038/s41467-020-18058-8. Nat Commun. 2020. PMID: 32826914 Free PMC article.
Highly Specific Mouse Anti-Joining Chain of Human Immunoglobulin A.
Ejemel M, Gawron MA, Schneider MI, Wallace A, Schiller ZA, Schneider R, Martin Iii JC, Klempner MS, Wang Y, Cavacini LA. Ejemel M, et al. Among authors: klempner ms. Monoclon Antib Immunodiagn Immunother. 2020 Dec;39(6):228-232. doi: 10.1089/mab.2020.0031. Epub 2020 Oct 29. Monoclon Antib Immunodiagn Immunother. 2020. PMID: 33121367
Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design.
Amcheslavsky A, Wallace AL, Ejemel M, Li Q, McMahon CT, Stoppato M, Giuntini S, Schiller ZA, Pondish JR, Toomey JR, Schneider RM, Meisinger J, Heukers R, Kruse AC, Barry EM, Pierce BG, Klempner MS, Cavacini LA, Wang Y. Amcheslavsky A, et al. Among authors: klempner ms. Sci Rep. 2021 Feb 2;11(1):2751. doi: 10.1038/s41598-021-81895-0. Sci Rep. 2021. PMID: 33531570 Free PMC article.
Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection.
Giuntini S, Stoppato M, Sedic M, Ejemel M, Pondish JR, Wisheart D, Schiller ZA, Thomas WD Jr, Barry EM, Cavacini LA, Klempner MS, Wang Y. Giuntini S, et al. Among authors: klempner ms. Infect Immun. 2018 Jul 23;86(8):e00355-18. doi: 10.1128/IAI.00355-18. Print 2018 Aug. Infect Immun. 2018. PMID: 29866909 Free PMC article.
IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity.
Ejemel M, Li Q, Hou S, Schiller ZA, Wallace AL, Amcheslavsky A, Yilmaz NK, Toomey JR, Schneider R, Close BJ, Chen DY, Conway HL, Mohsan S, Cavacini LA, Klempner MS, Schiffer CA, Wang Y. Ejemel M, et al. Among authors: klempner ms. bioRxiv [Preprint]. 2020 May 15:2020.05.15.096719. doi: 10.1101/2020.05.15.096719. bioRxiv. 2020. Update in: Nat Commun. 2020 Aug 21;11(1):4198. doi: 10.1038/s41467-020-18058-8 PMID: 32511396 Free PMC article. Updated. Preprint.
Correction for Giuntini et al., "Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection".
Giuntini S, Stoppato M, Sedic M, Ejemel M, Pondish JR, Wisheart D, Schiller ZA, Thomas WD Jr, Barry EM, Cavacini LA, Klempner MS, Wang Y. Giuntini S, et al. Among authors: klempner ms. Infect Immun. 2018 Nov 20;86(12):e00713-18. doi: 10.1128/IAI.00713-18. Print 2018 Dec. Infect Immun. 2018. PMID: 30459206 Free PMC article. No abstract available.
Blocking Borrelia burgdorferi transmission from infected ticks to nonhuman primates with a human monoclonal antibody.
Schiller ZA, Rudolph MJ, Toomey JR, Ejemel M, LaRochelle A, Davis SA, Lambert HS, Kern A, Tardo AC, Souders CA, Peterson E, Cannon RD, Ganesa C, Fazio F, Mantis NJ, Cavacini LA, Sullivan-Bolyai J, Hu LT, Embers ME, Klempner MS, Wang Y. Schiller ZA, et al. Among authors: klempner ms. J Clin Invest. 2021 Jun 1;131(11):e144843. doi: 10.1172/JCI144843. J Clin Invest. 2021. PMID: 33914704 Free PMC article.
126 results