Kopp A - Search Results

1

Antibody-Drug Conjugate Sacituzumab Govitecan Drives Efficient Tissue Penetration and Rapid Intracellular Drug Release.

Kopp A, Hofsess S, Cardillo TM, Govindan SV, Donnell J, Thurber GM. Kopp A, et al. Mol Cancer Ther. 2023 Jan 3;22(1):102-111. doi: 10.1158/1535-7163.MCT-22-0375. Mol Cancer Ther. 2023. PMID: 36190986 Free PMC article.

2

Increased Tumor Penetration of Single-Domain Antibody-Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models.

Nessler I, Khera E, Vance S, Kopp A, Qiu Q, Keating TA, Abu-Yousif AO, Sandal T, Legg J, Thompson L, Goodwin N, Thurber GM. Nessler I, et al. Among authors: kopp a. Cancer Res. 2020 Mar 15;80(6):1268-1278. doi: 10.1158/0008-5472.CAN-19-2295. Epub 2020 Jan 15. Cancer Res. 2020. PMID: 31941698 Free PMC article.

3

Severing Ties: Quantifying the Payload Release from Antibody Drug Conjugates.

Kopp A, Thurber GM. Kopp A, et al. Cell Chem Biol. 2019 Dec 19;26(12):1631-1633. doi: 10.1016/j.chembiol.2019.12.001. Cell Chem Biol. 2019. PMID: 31951577 Free PMC article.

4

Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping.

Khera E, Cilliers C, Smith MD, Ganno ML, Lai KC, Keating TA, Kopp A, Nessler I, Abu-Yousif AO, Thurber GM. Khera E, et al. Among authors: kopp a. Neoplasia. 2021 Feb;23(2):210-221. doi: 10.1016/j.neo.2020.12.001. Epub 2020 Dec 29. Neoplasia. 2021. PMID: 33385970 Free PMC article.

5

Predictive Simulations in Preclinical Oncology to Guide the Translation of Biologics.

Dong S, Nessler I, Kopp A, Rubahamya B, Thurber GM. Dong S, et al. Among authors: kopp a. Front Pharmacol. 2022 Mar 3;13:836925. doi: 10.3389/fphar.2022.836925. eCollection 2022. Front Pharmacol. 2022. PMID: 35308243 Free PMC article.

6

Improving Intracellular Delivery of an Antibody-Drug Conjugate Targeting Carcinoembryonic Antigen Increases Efficacy at Clinically Relevant Doses In Vivo.

Nessler I, Rubahamya B, Kopp A, Hofsess S, Cardillo TM, Sathyanarayan N, Donnell J, Govindan SV, Thurber GM. Nessler I, et al. Among authors: kopp a. Mol Cancer Ther. 2024 Mar 4;23(3):343-353. doi: 10.1158/1535-7163.MCT-23-0437. Mol Cancer Ther. 2024. PMID: 37913500 Free PMC article.

7

Impact of tissue penetration and albumin binding on design of T cell targeted bispecific agents.

Kopp A, Kwon H, Johnston C, Vance S, Legg J, Galson-Holt L, Thurber GM. Kopp A, et al. Neoplasia. 2024 Feb;48:100962. doi: 10.1016/j.neo.2023.100962. Epub 2024 Jan 5. Neoplasia. 2024. PMID: 38183712 Free PMC article.

8

In vivo Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies.

Kopp A, Dong S, Kwon H, Wang T, Desai AA, Linderman JJ, Tessier P, Thurber GM. Kopp A, et al. bioRxiv [Preprint]. 2024 Apr 10:2024.04.06.588433. doi: 10.1101/2024.04.06.588433. bioRxiv. 2024. PMID: 38645231 Free PMC article. Preprint.

9

Design of Crosslinking Antibodies For T-Cell Activation: Experimental and Computational Analysis of PD-1/CD137 Bispecific Agents.

Kopp A, Guan J, Johnston C, Vance S, Legg J, Galson-Holt L, Thurber GM. Kopp A, et al. AAPS J. 2024 Jun 11;26(4):68. doi: 10.1208/s12248-024-00937-3. AAPS J. 2024. PMID: 38862748

10

The Biological Effects of Magnesium-Based Implants on the Skeleton and Their Clinical Implications in Orthopedic Trauma Surgery.

Müller E, Schoberwalter T, Mader K, Seitz JM, Kopp A, Baranowsky A, Keller J. Müller E, et al. Among authors: kopp a. Biomater Res. 2024 Dec 23;28:0122. doi: 10.34133/bmr.0122. eCollection 2024. Biomater Res. 2024. PMID: 39717475 Free PMC article. Review.

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