Thurber GM - Search Results

1

Antibody-Drug Conjugate Sacituzumab Govitecan Drives Efficient Tissue Penetration and Rapid Intracellular Drug Release.

Kopp A, Hofsess S, Cardillo TM, Govindan SV, Donnell J, Thurber GM. Kopp A, et al. Among authors: thurber gm. Mol Cancer Ther. 2023 Jan 3;22(1):102-111. doi: 10.1158/1535-7163.MCT-22-0375. Mol Cancer Ther. 2023. PMID: 36190986 Free PMC article.

2

Improved Tumor Penetration and Single-Cell Targeting of Antibody-Drug Conjugates Increases Anticancer Efficacy and Host Survival.

Cilliers C, Menezes B, Nessler I, Linderman J, Thurber GM. Cilliers C, et al. Among authors: thurber gm. Cancer Res. 2018 Feb 1;78(3):758-768. doi: 10.1158/0008-5472.CAN-17-1638. Epub 2017 Dec 7. Cancer Res. 2018. PMID: 29217763 Free PMC article.

3

Increased Tumor Penetration of Single-Domain Antibody-Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models.

Nessler I, Khera E, Vance S, Kopp A, Qiu Q, Keating TA, Abu-Yousif AO, Sandal T, Legg J, Thompson L, Goodwin N, Thurber GM. Nessler I, et al. Among authors: thurber gm. Cancer Res. 2020 Mar 15;80(6):1268-1278. doi: 10.1158/0008-5472.CAN-19-2295. Epub 2020 Jan 15. Cancer Res. 2020. PMID: 31941698 Free PMC article.

4

Severing Ties: Quantifying the Payload Release from Antibody Drug Conjugates.

Kopp A, Thurber GM. Kopp A, et al. Among authors: thurber gm. Cell Chem Biol. 2019 Dec 19;26(12):1631-1633. doi: 10.1016/j.chembiol.2019.12.001. Cell Chem Biol. 2019. PMID: 31951577 Free PMC article.

5

Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody-Drug Conjugates to Increase In Vivo Efficacy.

Ponte JF, Lanieri L, Khera E, Laleau R, Ab O, Espelin C, Kohli N, Matin B, Setiady Y, Miller ML, Keating TA, Chari R, Pinkas J, Gregory R, Thurber GM. Ponte JF, et al. Among authors: thurber gm. Mol Cancer Ther. 2021 Jan;20(1):203-212. doi: 10.1158/1535-7163.MCT-20-0451. Epub 2020 Nov 11. Mol Cancer Ther. 2021. PMID: 33177153 Free PMC article.

6

Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping.

Khera E, Cilliers C, Smith MD, Ganno ML, Lai KC, Keating TA, Kopp A, Nessler I, Abu-Yousif AO, Thurber GM. Khera E, et al. Among authors: thurber gm. Neoplasia. 2021 Feb;23(2):210-221. doi: 10.1016/j.neo.2020.12.001. Epub 2020 Dec 29. Neoplasia. 2021. PMID: 33385970 Free PMC article.

7

Cellular-Resolution Imaging of Bystander Payload Tissue Penetration from Antibody-Drug Conjugates.

Khera E, Dong S, Huang H, de Bever L, van Delft FL, Thurber GM. Khera E, et al. Among authors: thurber gm. Mol Cancer Ther. 2022 Feb;21(2):310-321. doi: 10.1158/1535-7163.MCT-21-0580. Epub 2021 Dec 15. Mol Cancer Ther. 2022. PMID: 34911819 Free PMC article.

8

Predictive Simulations in Preclinical Oncology to Guide the Translation of Biologics.

Dong S, Nessler I, Kopp A, Rubahamya B, Thurber GM. Dong S, et al. Among authors: thurber gm. Front Pharmacol. 2022 Mar 3;13:836925. doi: 10.3389/fphar.2022.836925. eCollection 2022. Front Pharmacol. 2022. PMID: 35308243 Free PMC article.

9

Improving Intracellular Delivery of an Antibody-Drug Conjugate Targeting Carcinoembryonic Antigen Increases Efficacy at Clinically Relevant Doses In Vivo.

Nessler I, Rubahamya B, Kopp A, Hofsess S, Cardillo TM, Sathyanarayan N, Donnell J, Govindan SV, Thurber GM. Nessler I, et al. Among authors: thurber gm. Mol Cancer Ther. 2024 Mar 4;23(3):343-353. doi: 10.1158/1535-7163.MCT-23-0437. Mol Cancer Ther. 2024. PMID: 37913500 Free PMC article.

10

Impact of tissue penetration and albumin binding on design of T cell targeted bispecific agents.

Kopp A, Kwon H, Johnston C, Vance S, Legg J, Galson-Holt L, Thurber GM. Kopp A, et al. Among authors: thurber gm. Neoplasia. 2024 Feb;48:100962. doi: 10.1016/j.neo.2023.100962. Epub 2024 Jan 5. Neoplasia. 2024. PMID: 38183712 Free PMC article.

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