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A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.
Chan JF, Oh YJ, Yuan S, Chu H, Yeung ML, Canena D, Chan CC, Poon VK, Chan CC, Zhang AJ, Cai JP, Ye ZW, Wen L, Yuen TT, Chik KK, Shuai H, Wang Y, Hou Y, Luo C, Chan WM, Qin Z, Sit KY, Au WK, Legendre M, Zhu R, Hain L, Seferovic H, Tampé R, To KK, Chan KH, Thomas DG, Klausberger M, Xu C, Moon JJ, Stadlmann J, Penninger JM, Oostenbrink C, Hinterdorfer P, Yuen KY, Markovitz DM. Chan JF, et al. Among authors: penninger jm. Cell Rep Med. 2022 Oct 18;3(10):100774. doi: 10.1016/j.xcrm.2022.100774. Epub 2022 Sep 29. Cell Rep Med. 2022. PMID: 36195094 Free PMC article.
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.
Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM. Kuba K, et al. Among authors: penninger jm. Nat Med. 2005 Aug;11(8):875-9. doi: 10.1038/nm1267. Epub 2005 Jul 10. Nat Med. 2005. PMID: 16007097 Free PMC article.
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.
Monteil V, Kwon H, Prado P, Hagelkrüys A, Wimmer RA, Stahl M, Leopoldi A, Garreta E, Hurtado Del Pozo C, Prosper F, Romero JP, Wirnsberger G, Zhang H, Slutsky AS, Conder R, Montserrat N, Mirazimi A, Penninger JM. Monteil V, et al. Among authors: penninger jm. Cell. 2020 May 14;181(4):905-913.e7. doi: 10.1016/j.cell.2020.04.004. Epub 2020 Apr 24. Cell. 2020. PMID: 32333836 Free PMC article.
Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.
Monteil V, Dyczynski M, Lauschke VM, Kwon H, Wirnsberger G, Youhanna S, Zhang H, Slutsky AS, Hurtado Del Pozo C, Horn M, Montserrat N, Penninger JM, Mirazimi A. Monteil V, et al. Among authors: penninger jm. EMBO Mol Med. 2021 Jan 11;13(1):e13426. doi: 10.15252/emmm.202013426. Epub 2020 Dec 14. EMBO Mol Med. 2021. PMID: 33179852 Free PMC article.
Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.
Hoffmann D, Mereiter S, Jin Oh Y, Monteil V, Elder E, Zhu R, Canena D, Hain L, Laurent E, Grünwald-Gruber C, Klausberger M, Jonsson G, Kellner MJ, Novatchkova M, Ticevic M, Chabloz A, Wirnsberger G, Hagelkruys A, Altmann F, Mach L, Stadlmann J, Oostenbrink C, Mirazimi A, Hinterdorfer P, Penninger JM. Hoffmann D, et al. Among authors: penninger jm. EMBO J. 2021 Oct 1;40(19):e108375. doi: 10.15252/embj.2021108375. Epub 2021 Aug 23. EMBO J. 2021. PMID: 34375000 Free PMC article.
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury.
Yamaguchi T, Hoshizaki M, Minato T, Nirasawa S, Asaka MN, Niiyama M, Imai M, Uda A, Chan JF, Takahashi S, An J, Saku A, Nukiwa R, Utsumi D, Kiso M, Yasuhara A, Poon VK, Chan CC, Fujino Y, Motoyama S, Nagata S, Penninger JM, Kamada H, Yuen KY, Kamitani W, Maeda K, Kawaoka Y, Yasutomi Y, Imai Y, Kuba K. Yamaguchi T, et al. Among authors: penninger jm. Nat Commun. 2021 Nov 23;12(1):6791. doi: 10.1038/s41467-021-27097-8. Nat Commun. 2021. PMID: 34815389 Free PMC article.
640 results