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Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data.
Hughes SM, Levy CN, Katz R, Lokken EM, Anahtar MN, Hall MB, Bradley F, Castle PE, Cortez V, Doncel GF, Fichorova R, Fidel PL Jr, Fowke KR, Francis SC, Ghosh M, Hwang LY, Jais M, Jespers V, Joag V, Kaul R, Kyongo J, Lahey T, Li H, Makinde J, McKinnon LR, Moscicki AB, Novak RM, Patel MV, Sriprasert I, Thurman AR, Yegorov S, Mugo NR, Roxby AC, Micks E, Hladik F; Consortium for Assessing Immunity Across the Menstrual Cycle. Hughes SM, et al. BMC Med. 2022 Oct 5;20(1):353. doi: 10.1186/s12916-022-02532-9. BMC Med. 2022. PMID: 36195867 Free PMC article.
Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling.
Berard AR, Brubaker DK, Birse K, Lamont A, Mackelprang RD, Noël-Romas L, Perner M, Hou X, Irungu E, Mugo N, Knodel S, Muwonge TR, Katabira E, Hughes SM, Levy C, Calienes FL, Lauffenburger DA, Baeten JM, Celum C, Hladik F, Lingappa J, Burgener AD. Berard AR, et al. Among authors: hughes sm. Cell Rep. 2023 May 30;42(5):112474. doi: 10.1016/j.celrep.2023.112474. Epub 2023 May 6. Cell Rep. 2023. PMID: 37149863 Free PMC article.
Upregulation of IFN-stimulated genes persists beyond the transitory broad immunologic changes of acute HIV-1 infection.
Mackelprang RD, Filali-Mouhim A, Richardson B, Lefebvre F, Katabira E, Ronald A, Gray G, Cohen KW, Klatt NR, Pecor T, Celum C, McElrath MJ, Hughes SM, Hladik F, Cameron MJ, Lingappa JR; Partners in Prevention HSV/HIV Transmission Study; Partners PrEP Study Teams. Mackelprang RD, et al. Among authors: hughes sm. iScience. 2023 Mar 21;26(4):106454. doi: 10.1016/j.isci.2023.106454. eCollection 2023 Apr 21. iScience. 2023. PMID: 37020953 Free PMC article.
Computational Microbiome Pharmacology Analysis Elucidates the Anti-Cancer Potential of Vaginal Microbes and Metabolites.
Lawore DC, Jena S, Berard AR, Birse K, Lamont A, Mackelprang RD, Noel-Romas L, Perner M, Hou X, Irungu E, Mugo N, Knodel S, Muwonge TR, Katabira E, Hughes SM, Levy C, Calienes FL, Hladik F, Lingappa JR, Burgener AD, Green LN, Brubaker DK. Lawore DC, et al. Among authors: hughes sm. bioRxiv [Preprint]. 2024 Oct 17:2024.10.10.616351. doi: 10.1101/2024.10.10.616351. bioRxiv. 2024. PMID: 39416028 Free PMC article. Preprint.
Memory T cells possess an innate-like function in local protection from mucosal infection.
Arkatkar T, Davé V, Cruz Talavera I, Graham JB, Swarts JL, Hughes SM, Bell TA, Hock P, Farrington J, Shaw GD, Kirby A, Fialkow M, Huang ML, Jerome KR, Ferris MT, Hladik F, Schiffer JT, Prlic M, Lund JM. Arkatkar T, et al. Among authors: hughes sm. J Clin Invest. 2023 May 15;133(10):e162800. doi: 10.1172/JCI162800. J Clin Invest. 2023. PMID: 36951943 Free PMC article.
309 results