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Page 1
Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition.
Kücükdisli M, Bel-Abed H, Cirillo D, Lo WT, Efrém NL, Horatscheck A, Perepelittchenko L, Prokofeva P, Ehret TAL, Radetzki S, Neuenschwander M, Specker E, Médard G, Müller S, Wilhelm S, Kuster B, von Kries JP, Haucke V, Nazaré M. Kücükdisli M, et al. J Med Chem. 2023 Oct 26;66(20):14278-14302. doi: 10.1021/acs.jmedchem.3c01319. Epub 2023 Oct 11. J Med Chem. 2023. PMID: 37819647 Free PMC article.
Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Lo WT, Belabed H, Kücükdisli M, Metag J, Roske Y, Prokofeva P, Ohashi Y, Horatscheck A, Cirillo D, Krauss M, Schmied C, Neuenschwander M, von Kries JP, Médard G, Kuster B, Perisic O, Williams RL, Daumke O, Payrastre B, Severin S, Nazaré M, Haucke V. Lo WT, et al. Among authors: belabed h. Nat Chem Biol. 2023 Jan;19(1):18-27. doi: 10.1038/s41589-022-01118-z. Epub 2022 Sep 15. Nat Chem Biol. 2023. PMID: 36109648 Free PMC article.
An LPAR 5 -antagonist that reduces nociception and increases pruriception.
Langedijk J, Araya EI, Barroso AR, Tolenaars D, Nazaré M, Belabed H, Schoene J, Chichorro JG, Oude Elferink R. Langedijk J, et al. Among authors: belabed h. Front Pain Res (Lausanne). 2022 Jul 26;3:963174. doi: 10.3389/fpain.2022.963174. eCollection 2022. Front Pain Res (Lausanne). 2022. PMID: 35959236 Free PMC article.
Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer.
Li H, Prever L, Hsu MY, Lo WT, Margaria JP, De Santis MC, Zanini C, Forni M, Novelli F, Pece S, Di Fiore PP, Porporato PE, Martini M, Belabed H, Nazare M, Haucke V, Gulluni F, Hirsch E. Li H, et al. Among authors: belabed h. Adv Sci (Weinh). 2022 Mar;9(9):e2103249. doi: 10.1002/advs.202103249. Epub 2022 Jan 31. Adv Sci (Weinh). 2022. PMID: 35098698 Free PMC article.
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.
Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T. Schewe M, et al. Among authors: belabed h. Science. 2019 Feb 22;363(6429):875-880. doi: 10.1126/science.aav0569. Science. 2019. PMID: 30792303 Free PMC article.