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A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.
Kofink C, Trainor N, Mair B, Wöhrle S, Wurm M, Mischerikow N, Roy MJ, Bader G, Greb P, Garavel G, Diers E, McLennan R, Whitworth C, Vetma V, Rumpel K, Scharnweber M, Fuchs JE, Gerstberger T, Cui Y, Gremel G, Chetta P, Hopf S, Budano N, Rinnenthal J, Gmaschitz G, Mayer M, Koegl M, Ciulli A, Weinstabl H, Farnaby W. Kofink C, et al. Among authors: mclennan r. Nat Commun. 2022 Oct 10;13(1):5969. doi: 10.1038/s41467-022-33430-6. Nat Commun. 2022. PMID: 36216795 Free PMC article.
Targeting cancer with small-molecule pan-KRAS degraders.
Popow J, Farnaby W, Gollner A, Kofink C, Fischer G, Wurm M, Zollman D, Wijaya A, Mischerikow N, Hasenoehrl C, Prokofeva P, Arnhof H, Arce-Solano S, Bell S, Boeck G, Diers E, Frost AB, Goodwin-Tindall J, Karolyi-Oezguer J, Khan S, Klawatsch T, Koegl M, Kousek R, Kratochvil B, Kropatsch K, Lauber AA, McLennan R, Olt S, Peter D, Petermann O, Roessler V, Stolt-Bergner P, Strack P, Strauss E, Trainor N, Vetma V, Whitworth C, Zhong S, Quant J, Weinstabl H, Kuster B, Ettmayer P, Ciulli A. Popow J, et al. Among authors: mclennan r. Science. 2024 Sep 20;385(6715):1338-1347. doi: 10.1126/science.adm8684. Epub 2024 Sep 19. Science. 2024. PMID: 39298590
Comparative analysis of neural crest development in the chick and mouse.
Morrison JA, Pushel I, McLennan R, McKinney MC, Gogol MM, Scott A, Krumlauf R, Kulesa PM. Morrison JA, et al. Among authors: mclennan r. Dev Biol. 2024 Dec 21;519:142-149. doi: 10.1016/j.ydbio.2024.12.014. Online ahead of print. Dev Biol. 2024. PMID: 39716593
SARS-CoV-2 envelope protein regulates innate immune tolerance.
Geanes ES, McLennan R, Pierce SH, Menden HL, Paul O, Sampath V, Bradley T. Geanes ES, et al. Among authors: mclennan r. iScience. 2024 May 15;27(6):109975. doi: 10.1016/j.isci.2024.109975. eCollection 2024 Jun 21. iScience. 2024. PMID: 38827398 Free PMC article.
The cellular and immunological dynamics of early and transitional human milk.
LeMaster C, Pierce SH, Geanes ES, Khanal S, Elliott SS, Scott AB, Louiselle DA, McLennan R, Maulik D, Lewis T, Pastinen T, Bradley T. LeMaster C, et al. Among authors: mclennan r. Commun Biol. 2023 May 18;6(1):539. doi: 10.1038/s42003-023-04910-2. Commun Biol. 2023. PMID: 37202439 Free PMC article.
82 results