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Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.
Liu H, Stepicheva NA, Ghosh S, Shang P, Chowdhury O, Daley RA, Yazdankhah M, Gupta U, Hose SL, Valapala M, Fitting CS, Strizhakova A, Shan Y, Feenstra D, Sahel JA, Jayagopal A, Handa JT, Zigler JS Jr, Fort PE, Sodhi A, Sinha D. Liu H, et al. Among authors: ghosh s. Nat Commun. 2022 Oct 13;13(1):6045. doi: 10.1038/s41467-022-33773-0. Nat Commun. 2022. PMID: 36229454 Free PMC article.
The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling.
Shang P, Valapala M, Grebe R, Hose S, Ghosh S, Bhutto IA, Handa JT, Lutty GA, Lu L, Wan J, Qian J, Sergeev Y, Puertollano R, Zigler JS Jr, Xu GT, Sinha D. Shang P, et al. Among authors: ghosh s. Aging Cell. 2017 Apr;16(2):349-359. doi: 10.1111/acel.12561. Epub 2017 Jan 13. Aging Cell. 2017. PMID: 28083894 Free PMC article.
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease.
Yazdankhah M, Shang P, Ghosh S, Bhutto IA, Stepicheva N, Grebe R, Hose S, Weiss J, Luo T, Mishra S, Riazuddin SA, Ghosh A, Handa JT, Lutty GA, Zigler JS Jr, Sinha D. Yazdankhah M, et al. Among authors: ghosh s, ghosh a. Autophagy. 2020 Jun;16(6):1130-1142. doi: 10.1080/15548627.2019.1660545. Epub 2019 Sep 1. Autophagy. 2020. PMID: 31462148 Free PMC article.
Neutrophils homing into the retina trigger pathology in early age-related macular degeneration.
Ghosh S, Padmanabhan A, Vaidya T, Watson AM, Bhutto IA, Hose S, Shang P, Stepicheva N, Yazdankhah M, Weiss J, Das M, Gopikrishna S, Aishwarya, Yadav N, Berger T, Mak TW, Xia S, Qian J, Lutty GA, Jayagopal A, Zigler JS Jr, Sethu S, Handa JT, Watkins SC, Ghosh A, Sinha D. Ghosh S, et al. Among authors: ghosh a. Commun Biol. 2019 Sep 20;2:348. doi: 10.1038/s42003-019-0588-y. eCollection 2019. Commun Biol. 2019. PMID: 31552301 Free PMC article.
The role of lipocalin-2 in age-related macular degeneration (AMD).
Ghosh S, Stepicheva N, Yazdankhah M, Shang P, Watson AM, Hose S, Liu H, Weiss J, Zigler JS Jr, Valapala M, Watkins SC, Sinha D. Ghosh S, et al. Cell Mol Life Sci. 2020 Mar;77(5):835-851. doi: 10.1007/s00018-019-03423-8. Epub 2020 Jan 4. Cell Mol Life Sci. 2020. PMID: 31901947 Free PMC article. Review.
Role of glia in optic nerve.
Yazdankhah M, Shang P, Ghosh S, Hose S, Liu H, Weiss J, Fitting CS, Bhutto IA, Zigler JS Jr, Qian J, Sahel JA, Sinha D, Stepicheva NA. Yazdankhah M, et al. Among authors: ghosh s. Prog Retin Eye Res. 2021 Mar;81:100886. doi: 10.1016/j.preteyeres.2020.100886. Epub 2020 Aug 6. Prog Retin Eye Res. 2021. PMID: 32771538 Free PMC article. Review.
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